It is widely accepted that β-amyloid oligomers (Aβos) play a key role in the progression of
Alzheimer's disease (AD) by inducing neuron damage and cognitive impairment, but Aβos …

Olfactory neuropathology is a cause of olfactory loss in Alzheimer's disease (AD). Olfactory
dysfunction is also associated with memory and cognitive dysfunction and is an incidental …

Hypothalamic glial cells named tanycytes, which line the 3rd ventricle (3V), are components
of the hypothalamic network that regulates a diverse array of metabolic functions for energy …

The sense of smell has been shown to deteriorate in patients with some neurodegenerative
disorders. In Parkinson's disease (PD) and Alzheimer's disease (AD), decreased ability to …

Despite clinical evidence indicating a close relationship between olfactory dysfunction and
Alzheimer's disease (AD), further investigations are warranted to determine the diagnostic …

Introduction Basic studies suggest that olfactory dysfunction and functional near-infrared
spectroscopy (fNIRS) can be used as tools for the diagnosis of mild cognitive impairment …

Olfactory dysfunction is considered a pre-cognitive biomarker of Alzheimer's disease (AD).
Because the olfactory system is highly conserved across species, mouse models …

Evidence has mounted that insulin can be synthesized in various brain regions, including
the hypothalamus. However, the distribution and functions of insulin-expressing cells in the …

Olfaction declines with aging and appears to be a prodromal sign of cognitive decline in
progressive neurodegenerative diseases. Nevertheless, very little is known about the …

Olfaction is an important mechanism by which humans and animals communicate with
environment. Odorant-binding proteins (OBPs) play crucial role in the olfactory mechanism …