The toxicity and polymorphism of β-amyloid oligomers
Y Huang, R Liu - International journal of molecular sciences, 2020 - mdpi.com
It is widely accepted that β-amyloid oligomers (Aβos) play a key role in the progression of
Alzheimer's disease (AD) by inducing neuron damage and cognitive impairment, but Aβos …
Alzheimer's disease (AD) by inducing neuron damage and cognitive impairment, but Aβos …
[HTML][HTML] Olfactory neuropathology in Alzheimer's disease: a sign of ongoing neurodegeneration
Olfactory neuropathology is a cause of olfactory loss in Alzheimer's disease (AD). Olfactory
dysfunction is also associated with memory and cognitive dysfunction and is an incidental …
dysfunction is also associated with memory and cognitive dysfunction and is an incidental …
Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance
Hypothalamic glial cells named tanycytes, which line the 3rd ventricle (3V), are components
of the hypothalamic network that regulates a diverse array of metabolic functions for energy …
of the hypothalamic network that regulates a diverse array of metabolic functions for energy …
Alzheimer's disease: what can we learn from the peripheral olfactory system?
M Dibattista, S Pifferi, A Menini, J Reisert - Frontiers in Neuroscience, 2020 - frontiersin.org
The sense of smell has been shown to deteriorate in patients with some neurodegenerative
disorders. In Parkinson's disease (PD) and Alzheimer's disease (AD), decreased ability to …
disorders. In Parkinson's disease (PD) and Alzheimer's disease (AD), decreased ability to …
Longitudinal profiling of oligomeric Aβ in human nasal discharge reflecting cognitive decline in probable Alzheimer's disease
Despite clinical evidence indicating a close relationship between olfactory dysfunction and
Alzheimer's disease (AD), further investigations are warranted to determine the diagnostic …
Alzheimer's disease (AD), further investigations are warranted to determine the diagnostic …
Novel diagnostic tools for identifying cognitive impairment using olfactory-stimulated functional near-infrared spectroscopy: patient-level, single-group, diagnostic trial
Introduction Basic studies suggest that olfactory dysfunction and functional near-infrared
spectroscopy (fNIRS) can be used as tools for the diagnosis of mild cognitive impairment …
spectroscopy (fNIRS) can be used as tools for the diagnosis of mild cognitive impairment …
Olfactory evaluation in Alzheimer's disease model mice
J Zhang, Z Zhao, S Sun, J Li, Y Wang, J Dong, S Yang… - Brain Sciences, 2022 - mdpi.com
Olfactory dysfunction is considered a pre-cognitive biomarker of Alzheimer's disease (AD).
Because the olfactory system is highly conserved across species, mouse models …
Because the olfactory system is highly conserved across species, mouse models …
[HTML][HTML] Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production
J Lee, K Kim, JH Cho, JY Bae, TP O'Leary… - JCI insight, 2020 - ncbi.nlm.nih.gov
Evidence has mounted that insulin can be synthesized in various brain regions, including
the hypothalamus. However, the distribution and functions of insulin-expressing cells in the …
the hypothalamus. However, the distribution and functions of insulin-expressing cells in the …
Progressive signaling changes in the olfactory nerve of patients with Alzheimer's disease
P Bathini, A Mottas, M Jaquet, E Brai, L Alberi - Neurobiology of aging, 2019 - Elsevier
Olfaction declines with aging and appears to be a prodromal sign of cognitive decline in
progressive neurodegenerative diseases. Nevertheless, very little is known about the …
progressive neurodegenerative diseases. Nevertheless, very little is known about the …
[HTML][HTML] Odorant Binding Proteins: a key player in the sense of smell
G Archunan - Bioinformation, 2018 - ncbi.nlm.nih.gov
Olfaction is an important mechanism by which humans and animals communicate with
environment. Odorant-binding proteins (OBPs) play crucial role in the olfactory mechanism …
environment. Odorant-binding proteins (OBPs) play crucial role in the olfactory mechanism …