Imaging extracellular vesicles: current and emerging methods

STY Chuo, JCY Chien, CPK Lai - Journal of biomedical science, 2018 - Springer
Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles released by cells. They
range from 30 nm to several micrometers in diameter, and ferry biological cargos such as …

In vivo molecular bioluminescence imaging: new tools and applications

L Mezzanotte, M van't Root, H Karatas, EA Goun… - Trends in …, 2017 - cell.com
in vivo bioluminescence imaging (BLi) is an optical molecular imaging technique used to
visualize molecular and cellular processes in health and diseases and to follow the fate of …

Multiplexed epitope-based tissue imaging for discovery and healthcare applications

B Bodenmiller - Cell systems, 2016 - cell.com
The study of organs and tissues on a molecular level is necessary as we seek an
understanding of health and disease. Over the last few years, powerful highly multiplexed …

Future cancer research priorities in the USA: a Lancet Oncology Commission

EM Jaffee, C Van Dang, DB Agus… - The Lancet …, 2017 - thelancet.com
We are in the midst of a technological revolution that is providing new insights into human
biology and cancer. In this era of big data, we are amassing large amounts of information …

In vivo migration of mesenchymal stem cells to burn injury sites and their therapeutic effects in a living mouse model

EJ Oh, HW Lee, S Kalimuthu, TJ Kim, HM Kim… - Journal of Controlled …, 2018 - Elsevier
Mesenchymal stem cell (MSC)-based therapy has emerged as a promising therapeutic
strategy for tissue regeneration and repair. In this study, we non-invasively monitored the …

Current perspectives on in vivo noninvasive tracking of extracellular vesicles with molecular imaging

P Gangadaran, CM Hong… - BioMed research …, 2017 - Wiley Online Library
Clinical and preclinical in vivo tracking of extracellular vesicles (EVs) are a crucial tool for
the development and optimization of EV‐based diagnosis and treatment. EVs have gained …

Molecular imaging with reporter genes: has its promise been delivered?

I Serganova, RG Blasberg - Journal of Nuclear Medicine, 2019 - Soc Nuclear Med
The first reporter systems were developed in the early 1980s and were based on measuring
the activity of an enzyme—as a surrogate measure of promoter-driven transcriptional activity …

The immunoimaging toolbox

AT Mayer, SS Gambhir - Journal of Nuclear Medicine, 2018 - Soc Nuclear Med
The recent clinical success of cancer immunotherapy has renewed interest in the
development of tools to image the immune system. In general, immunotherapies attempt to …

Molecular imaging of innate immunity and immunotherapy

W Xia, N Singh, S Goel, S Shi - Advanced Drug Delivery Reviews, 2023 - Elsevier
The innate immune system plays a key role as the first line of defense in various human
diseases including cancer, cardiovascular and inflammatory diseases. In contrast to tissue …

Advances in Molecular Imaging Strategies for In Vivo Tracking of Immune Cells

HW Lee, P Gangadaran, S Kalimuthu… - BioMed research …, 2016 - Wiley Online Library
Tracking of immune cells in vivo is a crucial tool for development and optimization of cell‐
based therapy. Techniques for tracking immune cells have been applied widely for …