PTPN22 encodes a tyrosine phosphatase that is expressed by haematopoietic cells and
functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signalling …

Rheumatoid arthritis is an autoimmune disease that affects several organs and tissues,
predominantly the synovial joints. The pathogenesis of this disease is not completely …

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. As with other
complex traits, genome-wide association studies (GWASs) have tremendously enhanced …

Rheumatoid arthritis (RA) is a common autoimmune disease that results in significant
morbidity. As with other complex disorders, genome-wide association studies (GWASs) have …

Does age substantially affect the emergence of human immune-mediated arthritis? Children
do not usually develop immune-mediated articular inflammation during their first year of life …

Vitiligo is characterized by a skin depigmentation disorder resulting from an autoimmune
response targeting melanocytes. Within the genetic factors involved in the development of …

There is now growing evidence that autoimmunity is the common trait connecting multiple
clinical phenotypes albeit differences in tissue specificity, pathogenetic mechanisms, and …

How the Russian invasion affects Ukrainian rheumatological health care | Nature Reviews
Rheumatology Skip to main content Thank you for visiting nature.com. You are using a browser …

Rheumatoid arthritis (RA) is a chronic, inflammatory, multi-systemic autoimmune disease
unremitted by genetic and environmental factors. The factors are crucial but inadequate in …

The CTLA-4 protein is expressed in activated T cells and plays an essential role in the
immune response through its regulatory effect on T cell activation. Polymorphisms of the …