A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Viroporins are virus encoded proteins that alter membrane permeability and can trigger
subsequent cellular signals. Oligomerization of viroporin subunits results in formation of a …

Pestiviruses are among the economically most important pathogens of livestock. The biology
of these viruses is characterized by unique and interesting features that are both crucial for …

Viroporins are indispensable for viral replication. As intracellular ion channels they disturb
pH gradients of organelles and allow Ca 2+ flux across ER membranes. Viroporins interact …

A hallmark of hepatitis C virus (HCV) particles is their association with host cell lipids, most
notably lipoprotein components. It is thought that this property accounts for the low density of …

Hepatitis C virus (HCV) infection is a global health concern affecting an estimated 3% of the
world's population. Recently, cell culture systems have been established, allowing …

Over the last decade, there has been significant advances in the understanding of the cross-
talk between metabolism and immune responses. It is now evident that immune cell effector …

Hepatitis C virus (HCV) infection is associated with chronic liver disease and currently
affects about 3% of the world population. Although much has been learned about the …

Viruses of the Flaviviridae family, including hepatitis C, dengue and bovine viral diarrhoea,
are responsible for considerable morbidity and mortality worldwide. Recent advances in our …