Neprilysin is a zinc-dependent endopeptidase. It is ubiquitous in distribution and
promiscuous in function, with> 50 putative peptide substrates with varying levels of in vitro …

Background Resting heart rate is a risk factor of adverse heart failure outcomes; however,
studies have shown controversial results. This meta-analysis evaluates the association of …

Background Recent ESC guidelines on heart failure (HF) have introduced a new phenotype
based on left ventricular ejection fraction (LVEF), called the mid-range (HFmrEF). This …

Background Dogs with degenerative mitral valve disease are commonly presented to small
animal clinicians. Diagnosis, clinical staging, and therapeutic design are based on a …

Neprilysin (NEP) is a zinc-dependent metalloproteinase that exists in organisms in both
transmembrane and soluble forms. NEP substrates are involved in regulating the …

In the United States, the number of patients seeking surgical intervention in the ambulatory
setting continues to increase. As recently as 2012, elective surgery represented a major …

Introduction and objectives The specialty treating patients with heart failure (HF) has a
prognostic impact in the hospital setting but this issue remains under debate in the …

Background Dialysis patients are at increased risk of HF. However, diagnostic utility of NT-
proBNP as a biomarker is decreased in patients on dialysis. GDF-15 and cNEP are …

Background Our aim was to evaluate the association between the soluble form of neprilysin
(sNEP) levels and long‐term all‐cause, cardiovascular, and acute heart failure (AHF) …

Significant expression of neprilysin (NEP) is found on neutrophils, which present the
transmembrane integer form of the enzyme. This study aimed to investigate the relationship …