Therapeutic mechanisms of psychedelics and entactogens

BD Heifets, DE Olson - Neuropsychopharmacology, 2024 - nature.com
Recent clinical and preclinical evidence suggests that psychedelics and entactogens may
produce both rapid and sustained therapeutic effects across several indications. Currently …

Expectancy in placebo-controlled trials of psychedelics: if so, so what?

M Butler, L Jelen, J Rucker - Psychopharmacology, 2022 - Springer
Modern psychedelic research remains in an early phase, and the eventual introduction of
psychedelics into clinical practice remains in doubt. In this piece, we discuss the role of …

Investigational drugs for assisting psychotherapy for posttraumatic stress disorder (PTSD): emerging approaches and shifting paradigms in the era of psychedelic …

LA Averill, CG Abdallah - Expert Opinion on Investigational Drugs, 2022 - Taylor & Francis
The unfortunate reality of the mental health crisis plaguing much of the world, in tandem with
and exacerbated by the COVID-19 pandemic [1–3], highlights the limited effective …

Dark side of the shroom: Erasing indigenous and counterculture wisdoms with psychedelic capitalism, and the open source alternative: A manifesto for psychonauts

N Devenot, T Conner, R Doyle - Anthropology of …, 2022 - Wiley Online Library
Psychedelic or ecodelic medicines (eg, psilocybin, ayahuasca, iboga) for the care and
treatment of addiction, post‐traumatic stress disorder, cancer, cluster headaches, anxiety …

Can psychedelics enhance group psychotherapy? A discussion on the therapeutic factors

P Ponomarenko, F Seragnoli, A Calder… - Journal of …, 2023 - journals.sagepub.com
Background: Despite the growth of psychedelic research, psychedelic-assisted group
psychotherapy (PAGP) has received little attention in comparison to individual psychedelic …

Working with weirdness: A response to “moving past mysticism in psychedelic science”

JJ Breeksema, M Van Elk - ACS pharmacology & translational …, 2021 - ACS Publications
In response to a recent call to rid psychedelic science of the concept of mystical experience,
we argue that acknowledging the varieties and weirdness of psychedelic experiences …

Patient perspectives and experiences with psilocybin treatment for treatment-resistant depression: a qualitative study

JJ Breeksema, A Niemeijer, E Krediet, T Karsten… - Scientific reports, 2024 - nature.com
Psilocybin is the most researched classic psychedelic for Treatment-Resistant Depression
(TRD). While optimizing set and setting are considered essential for efficacy and safety …

Psychedelic identity shift: A critical approach to set and setting

N Devenot, A Seale-Feldman, E Smith… - Kennedy Institute of …, 2022 - muse.jhu.edu
While the literature on psychedelic medicine emphasizes the importance of set and setting
alongside the quality of subjective drug effects for therapeutic efficacy, few scholars have …

When the trial ends: the case for post-trial provisions in clinical psychedelic research

E Jacobs, A Murphy-Beiner, I Rouiller, D Nutt… - Neuroethics, 2024 - Springer
The ethical value—and to some scholars, necessity—of providing trial patients with post-trial
access (PTA) to an investigational drug has been subject to significant attention in the field …

Psychedelic innovations and the crisis of psychopharmacology

N Langlitz - BioSocieties, 2024 - Springer
In the 2010s, psychopharmacological research and development experienced a crisis: since
no genuinely new drugs for the treatment of mental illness had been successfully developed …