Although often located at a distance from their target gene promoters, enhancers are the
primary genomic determinants of temporal and spatial transcriptional specificity in …

Structural maintenance of chromosomes (SMC) complexes are essential proteins found in
genomes of all cellular organisms. Essential functions of these proteins, such as mitotic …

Dynamic chromatin behavior plays a critical role in various genome functions. However, it
remains unclear how chromatin behavior changes during interphase, where the nucleus …

Condensin is a structural maintenance of chromosomes (SMC) complex family member
thought to build mitotic chromosomes by DNA loop extrusion. However, condensin variants …

Targeted protein degradation, with its rapid protein depletion kinetics, allows the
measurement of acute changes in the cell. The auxin-inducible degron (AID) system, rapidly …

Underlying higher order chromatin organization are Structural Maintenance of
Chromosomes (SMC) complexes, large protein rings that entrap DNA. The molecular …

Eukaryotic genome DNA is wrapped around core histones and forms a nucleosome
structure. Together with associated proteins and RNAs, these nucleosomes are organized …

The structural maintenance of chromosome (SMC) complexes—cohesin and condensins—
are crucial for chromosome separation and compaction during cell division. During the …

Higher-order spatial organization of the chromatin in the nucleus plays crucial roles in the
maintenance of cell functions and the regulation of gene expression. Three-dimensional …

Chromosome organization and dynamics are involved in regulating many fundamental
processes such as gene transcription and DNA repair. Experiments unveiled that chromatin …