Multidrug resistance is one of the major obstacles in the treatment of cancers. This
undesirable feature increases the mortality rate of cancers, including breast cancer. Circular …

Simple Summary Cyclin-dependent kinases (CDKs) are rich and viable therapeutic targets
for various cancers. The emergence of event-driven pharmacology as an alternative to …

The differentiation of pluripotent stem cells (PSCs) into diverse functional cell types provides
a promising solution to support drug discovery, disease modeling, and regenerative …

Breast cancer displays high morbidity and mortality. Despite exerting certain effects,
traditional treatments cannot eliminate every cancer cell and may kill normal cells due to …

Prostate cancer is a prevalent malignancy among men globally, and androgen deprivation
therapy is the conventional first-line treatment for metastatic prostate cancer. While …

Sarcomas represent one of the most challenging tumor types to treat due to their diverse
nature and our incomplete understanding of their underlying biology. Recent work suggests …

Triple-negative breast cancer (TNBC) is an aggressive malignant disease that is responsible
for approximately 15% of breast cancers. The standard of care relies on surgery and …

Cyclin-dependent kinases (CDKs) belong to the serine/threonine kinase family, and their
unique interactions with a variety of cyclin complexes influence its catalytic activity to ensure …

Background Gastric cancer (GC) is a malignant tumor with a significantly high mortality rate,
yet, its pathogenesis is not fully understood. Bioinformatics predicted that LINC01224 is …

MicroRNAs (miRNAs) play a crucial role in maintaining the balance between the rapid
growth and suppression of tumorigenesis during antler regeneration. This study investigated …