Genetics and epigenetics of NAFLD and NASH: Clinical impact

M Eslam, L Valenti, S Romeo - Journal of hepatology, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …

Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease

Y Chen, X Du, A Kuppa, MF Feitosa, LF Bielak… - Nature …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no
effective treatments. We carried out a genome-wide association study (GWAS) meta …

Genetics of nonalcoholic fatty liver disease

P Dongiovanni, L Valenti - Metabolism, 2016 - Elsevier
Epidemiological, familial, and twin studies indicate that non-alcoholic fatty liver disease, now
the leading cause of liver damage in developed countries, has a strong heritability. The …

[HTML][HTML] Single-cell transcriptomics unveils gene regulatory network plasticity

G Iacono, R Massoni-Badosa, H Heyn - Genome biology, 2019 - Springer
Background Single-cell RNA sequencing (scRNA-seq) plays a pivotal role in our
understanding of cellular heterogeneity. Current analytical workflows are driven by …

[HTML][HTML] GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network

B Namjou, T Lingren, Y Huang, S Parameswaran… - BMC medicine, 2019 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with
a genetically heterogeneous background that can be accompanied by considerable …

[HTML][HTML] Machine learning enables new insights into genetic contributions to liver fat accumulation

ME Haas, JP Pirruccello, SN Friedman, M Wang… - Cell genomics, 2021 - cell.com
Excess liver fat, called hepatic steatosis, is a leading risk factor for end-stage liver disease
and cardiometabolic diseases but often remains undiagnosed in clinical practice because of …

[HTML][HTML] Advances in genetic variation in metabolism-related fatty liver disease

F Shi, M Zhao, S Zheng, L Zheng, H Wang - Frontiers in Genetics, 2023 - frontiersin.org
Metabolism-related fatty liver disease (MAFLD) is the most common form of chronic liver
disease in the world. Its pathogenesis is influenced by both environmental and genetic …

[HTML][HTML] Gene variants implicated in steatotic liver disease: opportunities for diagnostics and therapeutics

G Huang, DF Wallace, EE Powell, T Rahman, PJ Clark… - Biomedicines, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) describes a steatotic (or fatty) liver occurring as a
consequence of a combination of metabolic, environmental, and genetic factors, in the …

[HTML][HTML] Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα

RC Bauer, M Sasaki, DM Cohen, J Cui… - The Journal of …, 2015 - Am Soc Clin Investig
Variants near the gene TRIB1 are significantly associated with several plasma lipid traits,
circulating liver enzymes, and the development of coronary artery disease in humans; …

Long noncoding RNAs and atherosclerosis

T Zhou, J Ding, XA Wang, X Zheng - Atherosclerosis, 2016 - Elsevier
Atherosclerosis is universally recognized as a chronic lipid-induced inflammation of the
vessel wall in response to dyslipidemia and haemodynamic stress involving dysfunction and …