Genetics and epigenetics of NAFLD and NASH: Clinical impact
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …
disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis …
Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no
effective treatments. We carried out a genome-wide association study (GWAS) meta …
effective treatments. We carried out a genome-wide association study (GWAS) meta …
Genetics of nonalcoholic fatty liver disease
P Dongiovanni, L Valenti - Metabolism, 2016 - Elsevier
Epidemiological, familial, and twin studies indicate that non-alcoholic fatty liver disease, now
the leading cause of liver damage in developed countries, has a strong heritability. The …
the leading cause of liver damage in developed countries, has a strong heritability. The …
[HTML][HTML] Single-cell transcriptomics unveils gene regulatory network plasticity
Background Single-cell RNA sequencing (scRNA-seq) plays a pivotal role in our
understanding of cellular heterogeneity. Current analytical workflows are driven by …
understanding of cellular heterogeneity. Current analytical workflows are driven by …
[HTML][HTML] GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network
B Namjou, T Lingren, Y Huang, S Parameswaran… - BMC medicine, 2019 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with
a genetically heterogeneous background that can be accompanied by considerable …
a genetically heterogeneous background that can be accompanied by considerable …
[HTML][HTML] Machine learning enables new insights into genetic contributions to liver fat accumulation
Excess liver fat, called hepatic steatosis, is a leading risk factor for end-stage liver disease
and cardiometabolic diseases but often remains undiagnosed in clinical practice because of …
and cardiometabolic diseases but often remains undiagnosed in clinical practice because of …
[HTML][HTML] Advances in genetic variation in metabolism-related fatty liver disease
F Shi, M Zhao, S Zheng, L Zheng, H Wang - Frontiers in Genetics, 2023 - frontiersin.org
Metabolism-related fatty liver disease (MAFLD) is the most common form of chronic liver
disease in the world. Its pathogenesis is influenced by both environmental and genetic …
disease in the world. Its pathogenesis is influenced by both environmental and genetic …
[HTML][HTML] Gene variants implicated in steatotic liver disease: opportunities for diagnostics and therapeutics
Non-alcoholic fatty liver disease (NAFLD) describes a steatotic (or fatty) liver occurring as a
consequence of a combination of metabolic, environmental, and genetic factors, in the …
consequence of a combination of metabolic, environmental, and genetic factors, in the …
[HTML][HTML] Tribbles-1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα
Variants near the gene TRIB1 are significantly associated with several plasma lipid traits,
circulating liver enzymes, and the development of coronary artery disease in humans; …
circulating liver enzymes, and the development of coronary artery disease in humans; …
Long noncoding RNAs and atherosclerosis
T Zhou, J Ding, XA Wang, X Zheng - Atherosclerosis, 2016 - Elsevier
Atherosclerosis is universally recognized as a chronic lipid-induced inflammation of the
vessel wall in response to dyslipidemia and haemodynamic stress involving dysfunction and …
vessel wall in response to dyslipidemia and haemodynamic stress involving dysfunction and …