Over 30 nitrile-containing pharmaceuticals are prescribed for a diverse variety of medicinal
indications with more than 20 additional nitrile-containing leads in clinical development …

HIV reverse transcriptase (RT) inhibitors are the important components of highly active
antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in …

Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine was
adopted by WHO as a strategy to reduce HIV incidence. Although shown to be highly …

Drug resistance is a key cause of failure for treatment of HIV infection. The efficacy of non-
nucleoside reverse transcriptase inhibiting (NNRTI) drugs is impaired by rapid emergence of …

The critical issues in docking include the prediction of the correct binding pose and the
accurate estimation of the corresponding binding affinity. Different docking methodologies …

Microbicides have become a principal focus for HIV prevention strategies. The successful
design of drug delivery systems for vaginal microbicide drug candidates brings with it a …

Worldwide, nearly half of all individuals living with HIV are now women, who acquire the
virus largely by heterosexual exposure. With an HIV vaccine likely to be years away, topical …

Summary 25 years after the first HIV/AIDS cases emerged in 1981, the disease continues to
spread worldwide, with about 15 000 new infections every day. Although highly active …

Vaginal HIV microbicides are topical, self administered products designed to prevent or
significantly reduce transmission of HIV infection in women. The earliest microbicide …

Vaginal microbicides for the prevention of HIV transmission may be an important option for
protecting women from infection. Incorporation of dapivirine, a lead candidate …