Hydrophilic interaction liquid chromatography promotes the development of bio-separation and bio-analytical chemistry
Q Sheng, M Liu, M Lan, G Qing - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Hydrophilic interaction liquid chromatography (HILIC) has inherent advantages in the
separation of hydrophilic or strongly polar substances (eg, saccharides, glycopeptides …
separation of hydrophilic or strongly polar substances (eg, saccharides, glycopeptides …
Bispecific antibody-based immune-cell engagers and their emerging therapeutic targets in cancer immunotherapy
HG Shin, HR Yang, A Yoon, S Lee - International Journal of Molecular …, 2022 - mdpi.com
Cancer is the second leading cause of death worldwide after cardiovascular diseases.
Harnessing the power of immune cells is a promising strategy to improve the antitumor effect …
Harnessing the power of immune cells is a promising strategy to improve the antitumor effect …
High‐throughput glycosylation analysis of intact monoclonal antibodies by mass spectrometry coupled with capillary electrophoresis and liquid chromatography
L Naumann, P Schlossbauer, F Klingler… - Journal of …, 2022 - Wiley Online Library
The analysis of monoclonal antibodies glycosylation is a crucial quality control attribute of
biopharmaceutical drugs. High throughput screening approaches for antibody glycoform …
biopharmaceutical drugs. High throughput screening approaches for antibody glycoform …
[HTML][HTML] Size exclusion chromatography of biopharmaceutical products: From current practices for proteins to emerging trends for viral vectors, nucleic acids and lipid …
The 21 st century has been particularly productive for the biopharmaceutical industry, with
the introduction of several classes of innovative therapeutics, such as monoclonal …
the introduction of several classes of innovative therapeutics, such as monoclonal …
[HTML][HTML] A robust nanoscale RP HPLC-MS approach for sensitive Fc proteoform profiling of IgG allotypes
The conserved region (Fc) of IgG antibodies dictates the interactions with designated
receptors thus defining the immunological effector functions of IgG. Amino acid sequence …
receptors thus defining the immunological effector functions of IgG. Amino acid sequence …
Structural identification and absolute quantification of monoclonal antibodies in suspected counterfeits using capillary electrophoresis and liquid chromatography …
P Legrand, O Dembele, H Alamil, C Lamoureux… - Analytical and …, 2022 - Springer
Monoclonal antibodies (mAbs) represent a major category of biopharmaceutical products
which due to their success as therapeutics have recently experienced the emergence of …
which due to their success as therapeutics have recently experienced the emergence of …
Mass spectrometry study on SARS-CoV-2 recombinant vaccine with comprehensive separation techniques to characterize complex heterogeneity
G Wu, J Du, C Yu, Z Fu, X Zhang, L Wang, J Wang - Analytica Chimica Acta, 2024 - Elsevier
Abstract SARS-CoV-2, the causative agent of COVID-19, has imposed a major public health
threat, which needs effective therapeutics and vaccination strategies. Several potential …
threat, which needs effective therapeutics and vaccination strategies. Several potential …
CE-MS/MS and CE-timsTOF to separate and characterize intramolecular disulfide bridges of monoclonal antibody subunits and their application for the assessment of …
J Schairer, J Römer, D Lang, C Neusüß - Analytical and Bioanalytical …, 2024 - Springer
Abstract Characterization at the subunit level enables detailed mass spectrometric
characterization of posttranslational modifications (PTMs) of monoclonal antibodies (mAbs) …
characterization of posttranslational modifications (PTMs) of monoclonal antibodies (mAbs) …
Bispecific Antibodies in Targeted Cancer Immunotherapy
P Farhangnia, AA Delbandi, M Sadri… - Handbook of cancer and …, 2023 - Springer
Cancer immunotherapy focused on monoclonal antibodies (mAbs) has emerged as a
powerful tool in the armamentarium against tumors. In this regard, bispecific antibodies …
powerful tool in the armamentarium against tumors. In this regard, bispecific antibodies …
Characterization of charge variants, including post-translational modifications and proteoforms, of bispecific antigen-binding protein by cation-exchange …
Charge variant characterization of biologics is critical to ensure that product meets the
required quality and regulatory requirements to ensure safety and efficacy of the …
required quality and regulatory requirements to ensure safety and efficacy of the …