Decoding the role of miRNAs in multiple myeloma pathogenesis: a focus on signaling pathways
AM Yehia, EGE Elsakka, AI Abulsoud… - … -Research and Practice, 2023 - Elsevier
Multiple myeloma (MM) is a cancer of plasma cells that has been extensively studied in
recent years, with researchers increasingly focusing on the role of microRNAs (miRNAs) in …
recent years, with researchers increasingly focusing on the role of microRNAs (miRNAs) in …
Mir-34: a new weapon against cancer?
The microRNA (miRNA)-34a is a key regulator of tumor suppression. It controls the
expression of a plethora of target proteins involved in cell cycle, differentiation and …
expression of a plethora of target proteins involved in cell cycle, differentiation and …
miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review
Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely
investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence …
investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence …
Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: A first-in-human, phase 1, open …
Background We developed a 13-mer locked nucleic acid (LNA) inhibitor of miR-221 (LNA-i-
miR-221) with a full phosphorothioate (PS)-modified backbone. This agent downregulated …
miR-221) with a full phosphorothioate (PS)-modified backbone. This agent downregulated …
Potential value of miR-221/222 as diagnostic, prognostic, and therapeutic biomarkers for diseases
J Song, Y Ouyang, J Che, X Li, Y Zhao, K Yang… - Frontiers in …, 2017 - frontiersin.org
microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by base
pairing with their target messenger RNAs. Dysregulation of miRNAs is involved in the …
pairing with their target messenger RNAs. Dysregulation of miRNAs is involved in the …
Targeting miR-21 Inhibits In Vitro and In Vivo Multiple Myeloma Cell Growth
Purpose: Deregulated expression of miRNAs plays a role in the pathogenesis and
progression of multiple myeloma. Among upregulated miRNAs, miR-21 has oncogenic …
progression of multiple myeloma. Among upregulated miRNAs, miR-21 has oncogenic …
miRNAs and lncRNAs as novel therapeutic targets to improve cancer immunotherapy
Simple Summary Cancer onset and progression are promoted by high deregulation of the
immune system. Recently, major advances in molecular and clinical cancer immunology …
immune system. Recently, major advances in molecular and clinical cancer immunology …
miR-30-5p functions as a tumor suppressor and novel therapeutic tool by targeting the oncogenic Wnt/β-catenin/BCL9 pathway
Wnt/β-catenin signaling underlies the pathogenesis of a broad range of human cancers,
including the deadly plasma cell cancer multiple myeloma. In this study, we report that …
including the deadly plasma cell cancer multiple myeloma. In this study, we report that …
[HTML][HTML] Down-regulation of miR-221 inhibits proliferation of pancreatic cancer cells through up-regulation of PTEN, p27kip1, p57kip2, and PUMA
S Sarkar, H Dubaybo, S Ali, P Goncalves… - American journal of …, 2013 - ncbi.nlm.nih.gov
Pancreatic cancer is the fourth leading cause of cancer related death in the US and exhibits
aggressive features with short survival rate and high mortality. Therefore, it is important to …
aggressive features with short survival rate and high mortality. Therefore, it is important to …
Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism
G Antoniali, F Serra, L Lirussi, M Tanaka… - Nature …, 2017 - nature.com
Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in
genome stability and expression of genes involved in oxidative stress responses, tumor …
genome stability and expression of genes involved in oxidative stress responses, tumor …