Detection, production, modification, and application of arylsulfatases

M Yu, M Wu, F Secundo, Z Liu - Biotechnology Advances, 2023 - Elsevier
Arylsulfatase is a subset of sulfatase which catalyze the hydrolysis of aryl sulfate ester.
Arylsulfatase is widely distributed among microorganisms, mammals and green algae, but …

Sulfatases: critical enzymes for algal polysaccharide processing

AG Hettle, CJ Vickers, AB Boraston - Frontiers in Plant Science, 2022 - frontiersin.org
Microbial sulfatases are important biocatalysts in the marine environment where they play a
key role in the catabolic biotransformation of abundant sulphated algal polysaccharides. The …

[HTML][HTML] Application of MALDI-MS for characterization of fucoidan hydrolysates and screening of endo-fucoidanase activity

DS Reyes-Weiss, M Bligh, N Rhein-Knudsen… - Carbohydrate …, 2024 - Elsevier
Brown macroalgae synthesize large amounts of fucoidans, sulfated fucose-containing
polysaccharides, in the ocean. Fucoidans are of importance for their recently discovered …

Fucoidan-active α-L-fucosidases of the GH29 and GH95 families from a fucoidan degrading cluster of the marine bacterium Wenyingzhuangia fucanilytica

AS Silchenko, NK Rubtsov, AO Zueva… - Archives of Biochemistry …, 2022 - Elsevier
In present work we provide the bioinformatic and biochemical characterization of six α-L-
fucosidases that belong to the 29 and 95 families of glycoside hydrolases (GH) from the …

Structural tailoring of fucoidan backbones for maximizing their benefits: Enzymatic, chemical, and physical strategies

A Zayed, HTT Cao, VTD Trang, R Ulber - Journal of Applied Phycology, 2023 - Springer
Fucoidans are a heterogenous class of sulfated, fucose-rich, and high molecular weight
polysaccharides derived mainly from brown seaweeds. They have attracted particular …

The Discovery of the Fucoidan-Active Endo-1→ 4-α-L-Fucanase of the GH168 Family, Which Produces Fucoidan Derivatives with Regular Sulfation and Anticoagulant …

AS Silchenko, IV Taran, RV Usoltseva… - International Journal of …, 2023 - mdpi.com
Sulfated polysaccharides of brown algae, fucoidans, are known for their anticoagulant
properties, similar to animal heparin. Their complex and irregular structure is the main …

A recent update on fucoidonase: source, isolation methods and its enzymatic activity

N Barzkar, V Rungsardthong… - Frontiers in Marine …, 2023 - frontiersin.org
Fucoidanases are hydrolytic enzymes that degrade fucoidan to a lower molecular weight
while retaining the side substituent groups of the polymer. Fucoidanases are produced by …

Production of high-and low-molecular weight fucoidan fragments with defined sulfation patterns and heightened in vitro anticancer activity against TNBC cells using …

AO Zueva, AS Silchenko, AB Rasin… - Carbohydrate …, 2023 - Elsevier
Fucoidans are complex fucose-containing sulfated polysaccharides with pronounced
anticancer effects. Their structure-anticancer activity relationships are difficult to determine …

Marine bioprospecting, biocatalysis and process development

CJC Rodrigues, CCCR de Carvalho - Microorganisms, 2022 - mdpi.com
Oceans possess tremendous diversity in microbial life. The enzymatic machinery that marine
bacteria present is the result of extensive evolution to assist cell survival under the harsh …

Advances in structural modification of fucoidans, ulvans, and carrageenans to improve their biological functions for potential therapeutic application

S El Asri, RB Mrid, Z Zouaoui, Z Roussi, A Ennoury… - Carbohydrate …, 2024 - Elsevier
Marine sulfated polysaccharides constitute a class of bioactive polymers commonly found in
cell walls of macroalgae. Among these macromolecular substances, fucoidans, ulvans, and …