Genome-scale metabolic modeling for unraveling molecular mechanisms of high threat pathogens
Pathogens give rise to a wide range of diseases threatening global health and hence
drawing public health agencies' attention to establish preventative and curative solutions …
drawing public health agencies' attention to establish preventative and curative solutions …
Chemical descriptors, PASS, molecular docking, molecular dynamics and ADMET predictions of glucopyranoside derivatives as inhibitors to bacteria and fungi growth
SMA Kawsar, A Kumer, NS Munia… - Organic …, 2022 - search.proquest.com
The methyl α-D-glucopyranoside and its derivatives have been estimated as the
antimicrobial agents against numerous human pathogens, which is constantly amplifying the …
antimicrobial agents against numerous human pathogens, which is constantly amplifying the …
Uses of multi-objective flux analysis for optimization of microbial production of secondary metabolites
M Griesemer, A Navid - Microorganisms, 2023 - mdpi.com
Secondary metabolites are not essential for the growth of microorganisms, but they play a
critical role in how microbes interact with their surroundings. In addition to this important …
critical role in how microbes interact with their surroundings. In addition to this important …
Francisella tularensis as a potential agent of bioterrorism?
M Maurin - Expert Review of Anti-Infective Therapy, 2015 - Taylor & Francis
Francisella tularensis is a category A bioterrorism agent. It is the etiological agent of
tularemia, a zoonotic disease found throughout the northern hemisphere. The intentional …
tularemia, a zoonotic disease found throughout the northern hemisphere. The intentional …
Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new 3-deoxy-d-arabino-heptulosonate …
In Pseudomonas aeruginosa (Pae), the shikimate pathway end product, chorismate, serves
as the last common precursor for the biosynthesis of both primary aromatic metabolites …
as the last common precursor for the biosynthesis of both primary aromatic metabolites …
Diverse allosteric componentry and mechanisms control entry into aromatic metabolite biosynthesis
Highlights•DAH7PS is first enzyme of aromatic compound biosynthesis.•Allosteric regulation
of DAH7PS is important for metabolic control.•DAH7PS enzymes share a common catalytic …
of DAH7PS is important for metabolic control.•DAH7PS enzymes share a common catalytic …
A Pseudoisostructural Type II DAH7PS Enzyme from Pseudomonas aeruginosa: Alternative Evolutionary Strategies to Control Shikimate Pathway Flux
The shikimate pathway is responsible for the biosynthesis of key aromatic metabolites in
microorganisms and plants. The enzyme 3-deoxy-d-arabino-heptulosonate 7-phosphate …
microorganisms and plants. The enzyme 3-deoxy-d-arabino-heptulosonate 7-phosphate …
Functional and structural studies on the Neisseria gonorrhoeae GmhA, the first enzyme in the glycero‐manno‐heptose biosynthesis pathways, demonstrate a critical …
IH Wierzbicki, RA Zielke, KV Korotkov… - …, 2017 - Wiley Online Library
Abstract Sedoheptulose‐7‐phosphate isomerase, GmhA, is the first enzyme in the
biosynthesis of nucleotide‐activated‐glycero‐manno‐heptoses and an attractive, yet …
biosynthesis of nucleotide‐activated‐glycero‐manno‐heptoses and an attractive, yet …
Structural and functional characterization of M. tuberculosis sedoheptulose- 7-phosphate isomerase, a critical enzyme involved in lipopolysaccharide biosynthetic …
M. tuberculosis GmhA enzyme catalyzes the isomerization of D-sedoheptulose 7-phosphate
into D-glycero-D-α-manno-heptose-7-phosphate in GDP-D-glycero-α-D-manno-heptose …
into D-glycero-D-α-manno-heptose-7-phosphate in GDP-D-glycero-α-D-manno-heptose …
Role of Half-of-Sites Reactivity and Inter-Subunit Communications in DAHP Synthase Catalysis and Regulation
α-Carboxyketose synthases, including 3-deoxy-d-arabino heptulosonate 7-phosphate
synthase (DAHPS), are long-standing targets for inhibition. They are challenging targets to …
synthase (DAHPS), are long-standing targets for inhibition. They are challenging targets to …