Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …

Ageing is an inevitable event in the lifecycle of all organisms, characterized by progressive
physiological deterioration and increased vulnerability to death. Ageing has also been …

Neuronal cell loss is a defining feature of Alzheimer's disease (AD), but the underlying
mechanisms remain unclear. We xenografted human or mouse neurons into the brain of a …

INTRODUCTION Molecularly targeted drugs such as imatinib and crizotinib have
revolutionized the treatment of certain blood and lung cancers because of their remarkable …

Over the past 15 years, elegant studies have demonstrated that in certain conditions,
programed cell death resembles necrosis and depends on a unique molecular pathway with …

RIPK1 kinase has emerged as a promising therapeutic target for the treatment of a wide
range of human neurodegenerative, autoimmune, and inflammatory diseases. This was …

Necroptosis is a form of regulated cell death that critically depends on receptor-interacting
serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) and …

Understanding nephron loss is a primary strategy for preventing CKD progression. Death of
renal tubular cells may occur by apoptosis during developmental and regenerative …

The discovery of regulated cell death presents tantalizing possibilities for gaining control
over the life–death decisions made by cells in disease. Although apoptosis has been the …

In the last decade, the role of apoptosis in the pathophysiology of acute kidney injury (AKI)
and AKI to chronic kidney disease (CKD) progression has been revisited as our …