[HTML][HTML] Research progress of neuroblastoma related gene variations

Y Cao, Y Jin, J Yu, J Wang, J Yan, Q Zhao - Oncotarget, 2017 - ncbi.nlm.nih.gov
Neuroblastoma, the most common extracranial solid tumor among children, is an embryonal
tumor originating from undifferentiated neural crest cell. Neuroblastomas are highly …

[HTML][HTML] A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas

Z Lippai, B Péterfia, G Papp, K Dezső, G Bedics… - European Journal of …, 2024 - Elsevier
Introduction Dedifferentiated liposarcoma (DDLPS) is a common form of liposarcoma with
challenging treatment modalities. Pan-TRK immunopositivity can be often observed without …

Clinical significance of NTRK family gene expression in neuroblastomas

JE Light, H Koyama, JE Minturn, R Ho… - Pediatric blood & …, 2012 - Wiley Online Library
Abstract Background Neuroblastomas (NBs) are characterized by clinical heterogeneity,
from spontaneous regression to relentless progression. The pattern of NTRK family gene …

No association of polymorphisms in Nav1. 7 or nerve growth factor receptor genes with trigeminal neuralgia

GMF Costa, LPC Rocha, SRDT Siqueira… - Pain …, 2019 - academic.oup.com
Objective Trigeminal neuralgia is defined as a sudden severe shock-like pain within the
distribution of the trigeminal nerve. Pain is a subjective experience that is influenced by …

Point mutations in TRK inhibitor-resistant cancer and methods relating to the same

N Nanda, JH Bilenker, JF Blake… - US Patent …, 2021 - Google Patents
2019-02-06 Assigned to ARRAY BIOPHARMA INC. reassignment ARRAY BIOPHARMA
INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …

Process for the preparation of (S)-N-(5-((R)-2-(2, 5-difluorophenyl) pyrrolidin-1-yl)-pyrazolo [1, 5-a] pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide and salts …

M Reynolds, CT Eary, S Spencer, D Juengst… - US Patent …, 2022 - Google Patents
US11214571B2 - Process for the preparation of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
and salts thereof - Google Patents US11214571B2 - Process for the preparation of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide …

Macrocyclic compounds as ROS1 kinase inhibitors

SW Andrews, JF Blake, J Haas… - US Patent …, 2021 - Google Patents
2019-07-24 Assigned to ARRAY BIOPHARMA INC. reassignment ARRAY BIOPHARMA
INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS) …

Neurotrophin and neurotrophin receptor involvement in human neuroblastoma

P Ruggeri, AR Farina, L Cappabianca, N Di Ianni… - …, 2013 - books.google.com
Neuroblastoma (NB) isanembryonictumourthatoriginatesfromcell… (NC) arrested in their
differentiation at different stages along the sympatho-adrenal lineage and, less frequently …

Combinations for the treatment of neuroblastoma

ZD Hornby, G Li, DW Anderson, GM Brodeur… - US Patent …, 2018 - Google Patents
Disclosed are methods of treating neuroblastoma in a cancer patient by administration of a
Trk inhibitor in combination with one more chemotherapeutic agents. Also disclosed are …

Combinations for the treatment of neuroblastoma

ZD Hornby, G Li, DW Anderson, GM Brodeur… - US Patent …, 2019 - Google Patents
Disclosed are methods of treating neuroblastoma in a cancer patient by administration of a
Trk inhibitor in combination with one more chemotherapeutic agents. Also disclosed are …