Much remains to be learned about the pathogenesis of the different manifestations of
dengue virus (DENV) infections in humans. They may range from subclinical infection to …

INTRODUCTION: Dengue is a vector-borne viral infection that endangers an estimated 2.5
billion people. Disease caused by dengue ranges from a relatively minor febrile illness to a …

Background It is unclear whether dengue serotypes differ in their propensity to cause severe
disease. We analyzed differences in serotype-specific disease severity in children …

The complement system functions as an immune surveillance system that rapidly responds
to infection. Activation of the complement system by specific recognition pathways triggers a …

Dengue has become one of the most important worldwide arthropod-borne diseases.
Dengue phenotypes are based on laboratorial and clinical exams, which are known to be …

Background The complement system, a key component that links the innate and adaptive
immune responses, has three pathways: the classical, lectin, and alternative pathways. In …

Large case control gene association studies have been performed on cohorts of dengue
virus (DENV) infected patients identified in mainland Southeast Asia, South Asia and the …

Objective Severe dengue is a significant health problem in Latin America, with children
being the most affected. Understanding risk factors for severe dengue is crucial for …

An intact complement system is crucial for limiting West Nile virus (WNV) dissemination.
Herein, we define how complement directly restricts flavivirus infection in an antibody …

Dengue is a major worldwide problem in tropical and subtropical areas; it is caused by four
different viral serotypes, and it can manifest as asymptomatic, mild, or severe. Many factors …