Systemic lupus erythematosus (SLE) is characterized by high-titer serological
autoantibodies, including antibodies that bind to double-stranded DNA (dsDNA). The origin …

Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies
(Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their …

Imprecise targeting of chemotherapeutic drugs often leads to severe toxicity during breast
cancer therapy. To address this issue, we have devised a strategy to load dacarbazine (DC) …

Huntington's disease is associated with a reactive microglial response and consequent
inflammation. To address the role of these cells in disease pathogenesis, we depleted …

The human gastrointestinal mucosal surface consists of a eukaryotic epithelium, a
prokaryotic microbiota, and a carbohydrate-rich interface that separates them. In the …

ABSTRACT ADAMTS-1 is an extracellular protease with critical roles in organogenesis and
angiogenesis. Here we demonstrate a functional convergence of ADAMTS-1 and the …

Sanfilippo syndrome comprises a group of four genetic diseases due to the lack or
decreased activity of enzymes involved in heparan sulfate (HS) catabolism. HS …

Neurodegenerative diseases (NDDs) are associated with the accumulation of a range of
misfolded proteins across the central nervous system and related autoimmune responses …

Several enveloped viruses, including herpesviruses attach to host cells by initially
interacting with cell surface heparan sulfate (HS) proteoglycans followed by specific …

This review examines the roles of HS–proteoglycans (HS–PGs) in general, and, in
particular, perlecan and syndecan as representative examples and their interactive ligands …