In mammals, excess energy is stored primarily as triglycerides, which are mobilized when
energy demands arise. This review mainly focuses on the role of long chain fatty acids …

▪ Abstract Fatty acid desaturases introduce a double bond in a specific position of long-chain
fatty acids, and are conserved across kingdoms. Degree of unsaturation of fatty acids affects …

Fatty acid synthase (FAS) catalyzes the de novo synthesis of fatty acids. In the liver, FAS has
long been categorized as a housekeeping protein, producing fat for storage of energy when …

Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made
towards elucidating the mechanisms controlling the major regulatory pathways are now …

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

The liver is a central organ that controls systemic energy homeostasis and nutrient
metabolism. Dietary carbohydrates and lipids, and fatty acids derived from adipose tissue …

The liver plays a unique role in controlling carbohydrate metabolism by maintaining glucose
concentrations in a normal range over both short and long periods of times. In type 2 …

Hepatic glucokinase (GK) catalyzes the phosphorylation of glucose to glucose 6-phosphate
(G6P), a step which is essential for glucose metabolism in liver as well as for the induction of …

The regulation of hepatic glucose metabolism has a key role in whole-body energy
metabolism, since the liver is able to store (glycogen synthesis, lipogenesis) and to produce …

Carbohydrate response element (ChRE)-binding protein (ChREBP) is a recently discovered
transcription factor that is activated in response to high glucose concentrations in liver …