Ever since hematopoietic stem cells (HSCs) were first identified half a century ago, their
differentiation roadmap has been extensively studied. The classical model of hematopoiesis …

Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …

All blood cell lineages derive from a common hematopoietic stem cell (HSC). The current
model implicates that the first lineage commitment step of adult pluripotent HSCs results in a …

Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity …

Leukemia can be viewed as a newly formed, abnormal hematopoietic tissue initiated by a
few leukemic stem cells (LSCs) that undergo an aberrant and poorly regulated process of …

The role of cytokines in regulation of hematopoietic stem cells (HSCs) remains poorly
understood. Herein we demonstrate that thrombopoietin (THPO) and its receptor, MPL, are …

During'emergency'situations such as infections, host defense requires rapid mobilization of
bone marrow granulocyte progenitors.'Steady-state'granulopoiesis is absolutely dependent …

Abstract Cytokines IL-17 and IL-22 play pivotal roles in host defense against microbes and
in the development of chronic inflammatory diseases. These cytokines are produced by cells …

Intact cholesterol homeostasis helps to maintain hematopoietic stem and multipotential
progenitor cell (HSPC) quiescence. Mice with defects in cholesterol efflux pathways due to …

Attempts to improve hematopoietic reconstitution and engraftment potential of ex vivo–
expanded hematopoietic stem and progenitor cells (HSPCs) have been largely …