Large amounts of epidemiological evidence have confirmed the atmospheric particulate
matter (PM 2.5) exposure was positively correlated with the morbidity and mortality of …

Long interspersed nuclear element-1 (LINE-1) retrotransposition is a major hallmark of
cancer accompanied by global chromosomal instability, genomic instability, and genetic …

Abstract Background Long Interspersed Nuclear Element-1 (LINE-1, L1) is increasingly
regarded as a genetic risk for lung cancer. Transcriptionally active LINE-1 forms a L1-gene …

The mechanism underlying the development of tumors, particularly at early stages, still
remains mostly elusive. Here, we report whole-genome long and short read sequencing …

Lung squamous cell carcinoma (LUSC) is associated with high mortality and has few
therapeutic options. Chemotherapy remains the main treatment for LUSC patients, but multi …

Studies have demonstrated that arsenic (As) induces male reproductive injury, however, the
mechanism remains unknown. The high levels of arsenic (3) methyltransferase (As3MT) …

Triple-negative breast cancer (TNBC) is an aggressive disease characterized by remarkable
intratumor heterogeneity (ITH), which poses therapeutic challenges. However, the clinical …

Alternative splicing is an essential regulatory mechanism for development and
pathogenesis. Through alternative splicing one gene can encode multiple isoforms and be …

Over half of human genomic DNA is composed of repetitive sequences generated
throughout evolution by prolific mobile genetic parasites called transposable elements …

Energy metabolism is a hub of governing all processes at cellular and organismal levels
such as, on one hand, reparable vs. irreparable cell damage, cell fate (proliferation, survival …