Venoms as a platform for human drugs: translating toxins into therapeutics
GF King - Expert opinion on biological therapy, 2011 - Taylor & Francis
Introduction: An extraordinarily diverse range of animals have evolved venoms for predation,
defence, or competitor deterrence. The major components of most venoms are peptides and …
defence, or competitor deterrence. The major components of most venoms are peptides and …
Discovery, synthesis, and structure–activity relationships of conotoxins
Peptide therapeutics are acclaimed as a promising addition to the pharmaceutical arena,
and they continue to attract interest due to their high potency, bioavailability, and fewer …
and they continue to attract interest due to their high potency, bioavailability, and fewer …
Proline editing: A general and practical approach to the synthesis of functionally and structurally diverse peptides. Analysis of steric versus stereoelectronic effects of 4 …
AK Pandey, D Naduthambi, KM Thomas… - Journal of the …, 2013 - ACS Publications
Functionalized proline residues have diverse applications. Herein we describe a practical
approach, proline editing, for the synthesis of peptides with stereospecifically modified …
approach, proline editing, for the synthesis of peptides with stereospecifically modified …
Production of Recombinant Disulfide-Rich Venom Peptides for Structural and Functional Analysis via Expression in the Periplasm of E. coli
Disulfide-rich peptides are the dominant component of most animal venoms. These peptides
have received much attention as leads for the development of novel therapeutic agents and …
have received much attention as leads for the development of novel therapeutic agents and …
Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain
Poor oral availability and susceptibility to reduction and protease degradation is a major
hurdle in peptide drug development. However, drugable receptors in the gut present an …
hurdle in peptide drug development. However, drugable receptors in the gut present an …
The insecticidal potential of venom peptides
Pest insect species are a burden to humans as they destroy crops and serve as vectors for a
wide range of diseases including malaria and dengue. Chemical insecticides are currently …
wide range of diseases including malaria and dengue. Chemical insecticides are currently …
Natural and synthetic selenoproteins
N Metanis, D Hilvert - Current opinion in chemical biology, 2014 - Elsevier
Highlights•Selenocysteine endows proteins with novel redox properties.•New recombinant
and chemical methods are facilitating selenoprotein production.•Many natural …
and chemical methods are facilitating selenoprotein production.•Many natural …
Disulfide formation strategies in peptide synthesis
TM Postma, F Albericio - European Journal of Organic …, 2014 - Wiley Online Library
Disulfide bonds play an important role in both proteins and peptides. They cause
conformational constraints and increase the stability of such molecules. In nature, disulfide …
conformational constraints and increase the stability of such molecules. In nature, disulfide …
[PDF][PDF] Strategic use of non‐native diselenide bridges to steer oxidative protein folding
N Metanis, D Hilvert - Angewandte Chemie International Edition, 2012 - academia.edu
Oxidation of cysteine thiols to disulfides is a widespread posttranslational modification of
exported proteins, including many of pharmaceutical interest. For disulfide-rich proteins …
exported proteins, including many of pharmaceutical interest. For disulfide-rich proteins …
Substitution of an internal disulfide bridge with a diselenide enhances both foldability and stability of human insulin
O Weil‐Ktorza, N Rege, S Lansky… - … A European Journal, 2019 - Wiley Online Library
Insulin analogues, mainstays in the modern treatment of diabetes mellitus, exemplify the
utility of protein engineering in molecular pharmacology. Whereas chemical syntheses of the …
utility of protein engineering in molecular pharmacology. Whereas chemical syntheses of the …