Indole-fused azepines and analogues as anticancer lead molecules: privileged findings and future directions
The search for new lead compounds of simple structure, displaying highest quality anti-
tumor potency with new mechanisms of action and least adverse effects is the major …
tumor potency with new mechanisms of action and least adverse effects is the major …
The future of myeloma precision medicine: integrating the compendium of known drug resistance mechanisms with emerging tumor profiling technologies
Multiple myeloma (MM) is a hematologic malignancy that is considered mostly incurable in
large part due to the inability of standard of care therapies to overcome refractory disease …
large part due to the inability of standard of care therapies to overcome refractory disease …
[HTML][HTML] TNFRSF11B activates Wnt/β-catenin signaling and promotes gastric cancer progression
F Luan, X Li, X Cheng, L Huangfu, J Han… - … Journal of Biological …, 2020 - ncbi.nlm.nih.gov
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) has been studied to
be involved in the development and progression of several human malignancies. However …
be involved in the development and progression of several human malignancies. However …
[HTML][HTML] The therapeutic potential of cell cycle targeting in multiple myeloma
A Maes, E Menu, K De Veirman, K Maes, E De Bruyne - Oncotarget, 2017 - ncbi.nlm.nih.gov
Proper cell cycle progression through the interphase and mitosis is regulated by coordinated
activation of important cell cycle proteins (including cyclin-dependent kinases and mitotic …
activation of important cell cycle proteins (including cyclin-dependent kinases and mitotic …
[PDF][PDF] Drug targets and resistance mechanisms in multiple myeloma
J Nass, T Efferth - Cancer Drug Resist, 2018 - pdfs.semanticscholar.org
Multiple myeloma (MM), a malignancy of plasma cells, is the second most prevalent blood
cancer (10%). A PubMed search has been conducted for English research papers and …
cancer (10%). A PubMed search has been conducted for English research papers and …
Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo …
MN Semenova, AS Kiselyov, DV Tsyganov… - Journal of medicinal …, 2011 - ACS Publications
A series of 4-azapodophyllotoxin derivatives with modified rings B and E have been
synthesized using allylpolyalkoxybenzenes from parsley seed oil. The targeted molecules …
synthesized using allylpolyalkoxybenzenes from parsley seed oil. The targeted molecules …
[HTML][HTML] NMK-BH2, a novel microtubule-depolymerising bis (indolyl)-hydrazide-hydrazone, induces apoptotic and autophagic cell death in cervical cancer cells by …
Background Microtubules, the key components of the eukaryotic cytoskeleton and mitotic
spindle, are one of the most sought-after targets for cancer chemotherapy, especially due to …
spindle, are one of the most sought-after targets for cancer chemotherapy, especially due to …
Synthesis, anti-cancer evaluation of benzenesulfonamide derivatives as potent tubulin-targeting agents
A series of benzenesulfonamide derivatives were synthesized and evaluated for their anti-
proliferative activity and interaction with tubulin. These new derivatives showed significant …
proliferative activity and interaction with tubulin. These new derivatives showed significant …
[HTML][HTML] Chemical-proteomics identify Peroxiredoxin-1 as an actionable target in triple-negative breast cancer
E Spínola-Lasso, JC Montero… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) is difficult to treat; therefore, the development of drugs
directed against its oncogenic vulnerabilities is a desirable goal. Herein, we report the …
directed against its oncogenic vulnerabilities is a desirable goal. Herein, we report the …
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy
Autophagy is a lysosome dependent cell survival mechanism and is central to the
maintenance of organismal homeostasis in both physiological and pathological situations …
maintenance of organismal homeostasis in both physiological and pathological situations …