Cyclometalated iridium (III) luminescent complexes in therapy and phototherapy

A Zamora, G Vigueras, V Rodríguez… - Coordination Chemistry …, 2018 - Elsevier
Octahedral Ir (III) complexes bearing cyclometalated ligands exhibit a great stability in
biological media and are excellent therapeutical and phototherapeutical candidates for …

Organoiridium complexes: anticancer agents and catalysts

Z Liu, PJ Sadler - Accounts of Chemical Research, 2014 - ACS Publications
Conspectus Iridium is a relatively rare precious heavy metal, only slightly less dense than
osmium. Researchers have long recognized the catalytic properties of square-planar IrI …

[HTML][HTML] Advances in the design of organometallic anticancer complexes

P Zhang, PJ Sadler - Journal of Organometallic Chemistry, 2017 - Elsevier
Organometallic complexes containing ligands such as CO, carbenes, alkyls, phenyls, π-
bound alkynes, alkenes, cyclopentadienyls and arenes possess properties which have often …

Anticancer cyclometalated complexes of platinum group metals and gold

N Cutillas, GS Yellol, C de Haro, C Vicente… - Coordination chemistry …, 2013 - Elsevier
The clinical success of cisplatin and its derivatives has had an enormous impact on the
discovery of novel metal-based drugs. Extensive studies have focused on the interaction of …

The potent oxidant anticancer activity of organoiridium catalysts

Z Liu, I Romero‐Canelón, B Qamar… - Angewandte …, 2014 - Wiley Online Library
Platinum complexes are the most widely used anticancer drugs; however, new generations
of agents are needed. The organoiridium (III) complex [(η5‐Cpxbiph) Ir (phpy)(Cl)](1‐Cl) …

Redox‐active metal complexes for anticancer therapy

P Zhang, PJ Sadler - European Journal of Inorganic Chemistry, 2017 - Wiley Online Library
The redox properties of both metals and ligands in transition metal complexes offer unusual
routes for new mechanisms of anticancer therapy. Metal complexes can introduce artificial …

Cyclometalated [Cp* M (C^ X)](M= Ir, Rh; X= N, C, O, P) complexes

YF Han, GX Jin - Chemical Society Reviews, 2014 - pubs.rsc.org
Half-sandwich Cp* Ir and Cp* Rh metalacycles have been successfully applied in traditional
domains encompassing organic transformations and catalysis in recent years, especially the …

Iridium (III) complexes as therapeutic and bioimaging reagents for cellular applications

KKW Lo, KY Zhang - RSC advances, 2012 - pubs.rsc.org
There is an emerging interest in applying inorganic and organometallic transition metal
complexes to biomolecular and cellular studies. The cytotoxic effects of these complexes on …

Rhodium (III) and iridium (III) complexes as anticancer agents

Y Geldmacher, M Oleszak, WS Sheldrick - Inorganica Chimica Acta, 2012 - Elsevier
Until recently, Rh (III) and particularly Ir (III) complexes were generally considered as being
unlikely candidates for anticancer agents owing to the typical kinetic inertness of their …

A comprehensive and current review on the role of flavonoids in lung cancer–Experimental and theoretical approaches

Ş Berk, S Kaya, EK Akkol, H Bardakçı - Phytomedicine, 2022 - Elsevier
Background It is well-known that flavonoids, which can be easily obtained from many fruits
and vegetables are widely preferred in the treatment of some important diseases. Some …