Metabolomic epidemiology is the high-throughput study of the relationship between
metabolites and health-related traits. This emerging and rapidly growing field has improved …

The mercapturic acid pathway is a major route for the biotransformation of xenobiotic and
endobiotic electrophilic compounds and their metabolites. Mercapturic acids (N-acetyl-l …

Variation in the blood metabolome is intimately related to human health. However, few
details are known about the interplay between genetics and the microbiome in explaining …

Small molecules are extensively metabolized and cleared by the kidney. Changes in serum
metabolite concentrations may result from impaired kidney function and can be used to …

Metabolites are small molecules involved in cellular metabolism, which can be detected in
biological samples using metabolomic techniques. Here we present the results of genome …

Integrating genetic information with metabolomics has provided new insights into genes
affecting human metabolism. However, gene-metabolite integration has been primarily …

Background Type 2 diabetes mellitus (T2DM) is a chronic, metabolic disorder in which
concomitant insulin resistance and β-cell impairment lead to hyperglycemia, influenced by …

Aims/hypothesis The aims of this study were to evaluate systematically the predictive power
of comprehensive metabolomics profiles in predicting the future risk of type 2 diabetes, and …

Abstract The Consortium of Metabolomics Studies (COMETS) was established in 2014 to
facilitate large-scale collaborative research on the human metabolome and its relationship …

Genome-wide association studies with metabolomics (mGWAS) identify genetically
influenced metabotypes (GIMs), their ensemble defining the heritable part of every human's …