Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution

AA Pollen, U Kilik, CB Lowe, JG Camp - Nature Reviews Genetics, 2023 - nature.com
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

Clinical and biological characterization of skin pigmentation diversity and its consequences on UV impact

S Del Bino, C Duval, F Bernerd - International journal of molecular …, 2018 - mdpi.com
Skin color diversity is the most variable and noticeable phenotypic trait in humans resulting
from constitutive pigmentation variability. This paper will review the characterization of skin …

Loci associated with skin pigmentation identified in African populations

NG Crawford, DE Kelly, MEB Hansen, MH Beltrame… - Science, 2017 - science.org
INTRODUCTION Variation in pigmentation among human populations may reflect local
adaptation to regional light environments, because dark skin is more photoprotective …

Upper Palaeolithic genomes reveal deep roots of modern Eurasians

ER Jones, G Gonzalez-Fortes, S Connell… - Nature …, 2015 - nature.com
We extend the scope of European palaeogenomics by sequencing the genomes of Late
Upper Palaeolithic (13,300 years old, 1.4-fold coverage) and Mesolithic (9,700 years old …

Pleistocene North African genomes link near Eastern and sub-Saharan African human populations

M Van de Loosdrecht, A Bouzouggar, L Humphrey… - Science, 2018 - science.org
North Africa is a key region for understanding human history, but the genetic history of its
people is largely unknown. We present genomic data from seven 15,000-year-old modern …

Genomic diversity and admixture differs for Stone-Age Scandinavian foragers and farmers

P Skoglund, H Malmström, A Omrak, M Raghavan… - Science, 2014 - science.org
Prehistoric population structure associated with the transition to an agricultural lifestyle in
Europe remains a contentious idea. Population-genomic data from 11 Scandinavian Stone …

An unexpectedly complex architecture for skin pigmentation in Africans

AR Martin, M Lin, JM Granka, JW Myrick, X Liu… - Cell, 2017 - cell.com
Approximately 15 genes have been directly associated with skin pigmentation variation in
humans, leading to its characterization as a relatively simple trait. However, by assembling a …

Creating artificial human genomes using generative neural networks

B Yelmen, A Decelle, L Ongaro, D Marnetto… - PLoS …, 2021 - journals.plos.org
Generative models have shown breakthroughs in a wide spectrum of domains due to recent
advancements in machine learning algorithms and increased computational power. Despite …

The evolution of human skin pigmentation involved the interactions of genetic, environmental, and cultural variables

NG Jablonski - Pigment Cell & Melanoma Research, 2021 - Wiley Online Library
The primary biological role of human skin pigmentation is as a mediator of penetration of
ultraviolet radiation (UVR) into the deep layers of skin and the cutaneous circulation. Since …

Human adaptation to arsenic-rich environments

CM Schlebusch, LM Gattepaille… - Molecular biology …, 2015 - academic.oup.com
Adaptation drives genomic changes; however, evidence of specific adaptations in humans
remains limited. We found that inhabitants of the northern Argentinean Andes, an arid region …