Shadow enhancers are seemingly redundant transcriptional cis-regulatory elements that
regulate the same gene and drive overlapping expression patterns. Recent studies have …

A class of cis-regulatory elements, called enhancers, play a central role in orchestrating
spatiotemporally precise gene-expression programs during development. Consequently …

Each language has standard books describing that language's grammatical rules. Biologists
have searched for similar, albeit more complex, principles relating enhancer sequence to …

There is now compelling evidence that many arthropods pattern their segments using a
clock-and-wavefront mechanism, analogous to that operating during vertebrate …

Oscillatory and sequential processes have been implicated in the spatial patterning of many
embryonic tissues. For example, molecular clocks delimit segmental boundaries in …

The evolution of gene regulation is considered one of the main drivers causing the
astonishing morphological diversity in the animal kingdom. Gene regulation in animals …

Developmental patterning networks are regulated by multiple inputs and feedback
connections that rapidly reshape gene expression, limiting the information that can be …

Drosophila segmentation is a well-established paradigm for developmental pattern
formation. However, the later stages of segment patterning, regulated by the “pair-rule” …

Shadow enhancers, groups of seemingly redundant enhancers, are found in a wide range of
organisms and are critical for robust developmental patterning. However, their mechanism of …

The high-dimensional character of most biological systems presents genuine challenges for
modeling and prediction. Here we propose a neural network–based approach for …