Caspase-8 is a cysteine-aspartate specific protease that classically triggers the extrinsic
apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like …

The inactivation of programmed cell death has profound effects not only on the development
but also on the overall integrity of multicellular organisms. Beside developmental …

Alternative splicing is regulated by multiple RNA-binding proteins and influences the
expression of most eukaryotic genes. However, the role of this process in human disease …

Pancreatic cancer has the lowest survival rate among human cancers, and there are no
effective markers for its screening and early diagnosis. To identify genetic susceptibility …

Background: The functions of NF-κB in apoptosis and tumor development are controversial.
Results: Fas functions as a tumor suppressor, and NF-κB directly binds to multiple sites in …

Background Alcohol consumption is increasing worldwide and is associated with numerous
cancers. This systematic review examined the role of alcohol in the incidence of cancer in …

Tumor Necrosis Factor (TNF) alpha is a pleiotropic cytokine triggering either pro-
inflammatory effects via NF-κB related pathways or apoptosis through activation of caspase …

Fas/Fas ligand (FasL) system is one of the key apoptotic signaling entities in the extrinsic
apoptotic pathway. De-regulation of this pathway, ie by mutations may prevent the immune …

The death receptor Fas and its physiological ligand (FasL) regulate apoptosis of cancerous
cells, thereby functioning as a critical component of the host cancer immunosurveillance …

OBJECTIVES: The objective of this study was to examine the association between tobacco
and alcohol dose and type and the age of onset of pancreatic adenocarcinoma (PancCa) …