Strict regulation of DNA replication is of fundamental significance for the maintenance of
genome stability. Licensing of origins of DNA replication is a critical event for timely genome …

In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the
genetic material between generations requires timely and accurate duplication of DNA by …

Abstract CMG (Cdc45‐MCM‐GINS) helicase assembly at the replication origin is the
culmination of eukaryotic DNA replication initiation. This process can be reconstructed in …

In eukaryotes, DNA replication initiation requires assembly and activation of the
minichromosome maintenance (MCM) 2–7 double hexamer (DH) to melt origin DNA …

The chromatin-based rule governing the selection and activation of replication origins in
metazoans remains to be investigated. Here we report that NFIB, a member of Nuclear …

A versatile division of apicomplexan parasites and a dearth of conserved regulators have
hindered the progress of apicomplexan cell cycle studies. While most apicomplexans divide …

The initiation of DNA replication in metazoans occurs at thousands of chromosomal sites
known as origins. At each origin, the Origin Recognition Complex (ORC), Cdc6, and Cdt1 co …

Successful genome duplication is required for cell proliferation and demands extraordinary
precision and accuracy. The mechanisms by which cells enter, progress through, and exit S …

The initiation of DNA replication involves cell cycle-dependent assembly and disassembly of
protein complexes, including the origin recognition complex (ORC) and CDC6 AAA+ …

High-resolution structures have not been reported for replicative helicases at a replication
fork at atomic resolution, a prerequisite to understanding the unwinding mechanism. The …