Abstract mRNA surveillance pathways are essential for accurate gene expression and to
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …

Autoimmunity and autoinflammation arise from aberrant immunological and inflammatory
responses toward self-components, contributing to various autoimmune diseases and …

The ribosome-associated protein quality control (RQC) system that resolves stalled
translation events is activated when ribosomes collide and form disome, trisome, or higher …

Translation initiation is the major regulatory step defining the rate of protein production from
an mRNA. Meanwhile, the impact of nonuniform ribosomal elongation rates is largely …

When coined, the term “antisense” included oligonucleotides of any structure, with any
chemical modification and designed to work through any post-RNA hybridization …

Maternal mRNAs are essential for protein synthesis during oogenesis and early
embryogenesis. To adapt translation to specific needs during development, maternal …

Cells tightly regulate mRNA processing, localization, and stability to ensure accurate gene
expression in diverse cellular states and conditions. Most of these regulatory steps have …

Signaling pathways drive cell fate transitions largely by changing gene expression.
However, the mechanisms for rapid and selective transcriptome rewiring in response to …

Eukaryotic gene expression is closely regulated by translation and turnover of mRNAs.
Recent advances highlight the importance of translation in the control of mRNA degradation …

The superkiller (SKI) complex is the cytoplasmic co-factor and regulator of the RNA-
degrading exosome. In human cells, the SKI complex functions mainly in co-translational …