Abstract Collagen alpha-1 (III) chain, also known as the alpha 1 chain of type III collagen, is
a protein that in humans is encoded by the COL3A1 gene. Three alpha 1 chains are …

Cancers are complex ecosystems composed of malignant cells embedded in an intricate
microenvironment made of different non-transformed cell types and extracellular matrix …

The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …

Simple Summary Extracellular matrix is a three-dimensional network of macromolecules that
provide structural and biochemical support to surrounding cells. Extracellular matrix plays a …

Abstract Single-molecule Real-time Isoform Sequencing (Iso-seq) of transcriptomes by
PacBio can generate very long and accurate reads, thus providing an ideal platform for full …

In recent years, it has become increasingly evident that cancer cells and the local
microenvironment are crucial in the development and progression of tumors. One of the …

The tumor microenvironment (TME) is a complex structure comprised of tumor, immune and
stromal cells, vasculature, and extracellular matrix (ECM). During tumor development, ECM …

Progression through dissemination to tumor-surrounding tissues and metastasis
development is a hallmark of cancer that requires continuous cell-to-cell interactions and …

The tumor microenvironment (TME) has become the focus of interest in cancer research and
treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are …

Background Excessive extracellular matrix (ECM) remodeling and a reactive stroma can
affect T-cell infiltration and T-cell activity in the tumor and hereby influence response to …