Pre-eclampsia: pathogenesis, novel diagnostics and therapies

EA Phipps, R Thadhani, T Benzing… - Nature Reviews …, 2019 - nature.com
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …

Understanding the intersection between placental development and cancer: Lessons from the tumor suppressor BAP1

P Doria-Borrell, V Pérez-García - Communications Biology, 2024 - nature.com
The placenta, a pivotal organ in mammalian reproduction, allows nutrient exchange and
hormonal signaling between the mother and the developing fetus. Understanding its …

[HTML][HTML] Trophoblast cell subtypes and dysfunction in the placenta of individuals with preeclampsia revealed by single-cell RNA sequencing

W Zhou, H Wang, Y Yang, F Guo, B Yu, Z Su - Molecules and cells, 2022 - Elsevier
Trophoblasts, important functional cells in the placenta, play a critical role in maintaining
placental function. The heterogeneity of trophoblasts has been reported, but little is known …

Size-dependent maternal-fetal transfer and fetal developmental toxicity of ZnO nanoparticles after oral exposures in pregnant mice

C Teng, J Jia, Z Wang, VK Sharma, B Yan - … and Environmental Safety, 2019 - Elsevier
The widespread application of nanomaterial-based products has caused safety concerns
worldwide, especially for susceptible pregnant population. Here, we revealed the effect of …

ELABELA, as a potential diagnostic biomarker of preeclampsia, regulates abnormally shallow placentation via APJ

L Zhou, H Sun, R Cheng, X Fan… - American Journal of …, 2019 - journals.physiology.org
Preeclampsia (PE) is a major cause of maternal mortality and morbidity worldwide. Although
there has been great progress in the understanding of PE, the exact cause for the disease …

Severe anemia, sickle cell disease, and thalassemia as risk factors for hypertensive disorders in pregnancy in developing countries

C Chen, J Grewal, AP Betran, JP Vogel, JP Souza… - Pregnancy …, 2018 - Elsevier
Objective Hypertensive disorders during pregnancy are one of main causes for maternal
and perinatal morbidity and mortality in developing countries. This study is to determine …

The intervention effect of aspirin on a lipopolysaccharide-induced preeclampsia-like mouse model by inhibiting the nuclear factor-κB pathway

G Li, L Ma, L Lin, Y Wang, H Yang - Biology of Reproduction, 2018 - academic.oup.com
Preeclampsia is a severe pregnancy-related disorder, and patients usually present with high
circulating inflammatory factor levels and excessive activation of the nuclear factor-κB (NF …

Esomeprazole inhibits hypoxia/endothelial dysfunction–induced autophagy in preeclampsia

S Gu, C Zhou, J Pei, Y Wu, S Wan, X Zhao, J Hu… - Cell and Tissue …, 2022 - Springer
Abstract Preeclampsia (PE) affects 3 to 5% of pregnant women worldwide and is associated
with fetal and maternal morbidity and mortality. Although a complete understanding of PE …

Integrated bioinformatics analysis reveals novel key biomarkers and potential candidate small molecule drugs in gestational diabetes mellitus

V Alur, V Raju, B Vastrad, A Tengli, C Vastrad… - Bioscience …, 2021 - portlandpress.com
Gestational diabetes mellitus (GDM) is the metabolic disorder that appears during
pregnancy. The current investigation aimed to identify central differentially expressed genes …

Ligustrazine promotes hypoxia/reoxygenation-treated trophoblast cell proliferation and migration by regulating the microRNA-27a-3p/ATF3 axis

M Wang, L Zhang, X Huang, Q Sun - Archives of Biochemistry and …, 2023 - Elsevier
Objective Preeclampsia (PE) is a pregnancy-specific syndrome. Ligustrazine (LSZ) is
involved in hypoxia/reoxygenation (H/R)-treated trophoblast cell regulation, but its …