Pre-eclampsia: pathogenesis, novel diagnostics and therapies
EA Phipps, R Thadhani, T Benzing… - Nature Reviews …, 2019 - nature.com
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …
Understanding the intersection between placental development and cancer: Lessons from the tumor suppressor BAP1
P Doria-Borrell, V Pérez-García - Communications Biology, 2024 - nature.com
The placenta, a pivotal organ in mammalian reproduction, allows nutrient exchange and
hormonal signaling between the mother and the developing fetus. Understanding its …
hormonal signaling between the mother and the developing fetus. Understanding its …
[HTML][HTML] Trophoblast cell subtypes and dysfunction in the placenta of individuals with preeclampsia revealed by single-cell RNA sequencing
W Zhou, H Wang, Y Yang, F Guo, B Yu, Z Su - Molecules and cells, 2022 - Elsevier
Trophoblasts, important functional cells in the placenta, play a critical role in maintaining
placental function. The heterogeneity of trophoblasts has been reported, but little is known …
placental function. The heterogeneity of trophoblasts has been reported, but little is known …
Size-dependent maternal-fetal transfer and fetal developmental toxicity of ZnO nanoparticles after oral exposures in pregnant mice
The widespread application of nanomaterial-based products has caused safety concerns
worldwide, especially for susceptible pregnant population. Here, we revealed the effect of …
worldwide, especially for susceptible pregnant population. Here, we revealed the effect of …
ELABELA, as a potential diagnostic biomarker of preeclampsia, regulates abnormally shallow placentation via APJ
L Zhou, H Sun, R Cheng, X Fan… - American Journal of …, 2019 - journals.physiology.org
Preeclampsia (PE) is a major cause of maternal mortality and morbidity worldwide. Although
there has been great progress in the understanding of PE, the exact cause for the disease …
there has been great progress in the understanding of PE, the exact cause for the disease …
Severe anemia, sickle cell disease, and thalassemia as risk factors for hypertensive disorders in pregnancy in developing countries
Objective Hypertensive disorders during pregnancy are one of main causes for maternal
and perinatal morbidity and mortality in developing countries. This study is to determine …
and perinatal morbidity and mortality in developing countries. This study is to determine …
The intervention effect of aspirin on a lipopolysaccharide-induced preeclampsia-like mouse model by inhibiting the nuclear factor-κB pathway
G Li, L Ma, L Lin, Y Wang, H Yang - Biology of Reproduction, 2018 - academic.oup.com
Preeclampsia is a severe pregnancy-related disorder, and patients usually present with high
circulating inflammatory factor levels and excessive activation of the nuclear factor-κB (NF …
circulating inflammatory factor levels and excessive activation of the nuclear factor-κB (NF …
Esomeprazole inhibits hypoxia/endothelial dysfunction–induced autophagy in preeclampsia
S Gu, C Zhou, J Pei, Y Wu, S Wan, X Zhao, J Hu… - Cell and Tissue …, 2022 - Springer
Abstract Preeclampsia (PE) affects 3 to 5% of pregnant women worldwide and is associated
with fetal and maternal morbidity and mortality. Although a complete understanding of PE …
with fetal and maternal morbidity and mortality. Although a complete understanding of PE …
Integrated bioinformatics analysis reveals novel key biomarkers and potential candidate small molecule drugs in gestational diabetes mellitus
V Alur, V Raju, B Vastrad, A Tengli, C Vastrad… - Bioscience …, 2021 - portlandpress.com
Gestational diabetes mellitus (GDM) is the metabolic disorder that appears during
pregnancy. The current investigation aimed to identify central differentially expressed genes …
pregnancy. The current investigation aimed to identify central differentially expressed genes …
Ligustrazine promotes hypoxia/reoxygenation-treated trophoblast cell proliferation and migration by regulating the microRNA-27a-3p/ATF3 axis
M Wang, L Zhang, X Huang, Q Sun - Archives of Biochemistry and …, 2023 - Elsevier
Objective Preeclampsia (PE) is a pregnancy-specific syndrome. Ligustrazine (LSZ) is
involved in hypoxia/reoxygenation (H/R)-treated trophoblast cell regulation, but its …
involved in hypoxia/reoxygenation (H/R)-treated trophoblast cell regulation, but its …