The expanding regulatory mechanisms and cellular functions of circular RNAs

LL Chen - Nature reviews Molecular cell biology, 2020 - nature.com
Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs)
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …

The bioinformatics toolbox for circRNA discovery and analysis

L Chen, C Wang, H Sun, J Wang, Y Liang… - Briefings in …, 2021 - academic.oup.com
Circular RNAs (circRNAs) are a unique class of RNA molecule identified more than 40 years
ago which are produced by a covalent linkage via back-splicing of linear RNA. Recent …

New insight into circRNAs: characterization, strategies, and biomedical applications

XY Feng, SX Zhu, KJ Pu, HJ Huang, YQ Chen… - … Hematology & Oncology, 2023 - Springer
Circular RNAs (circRNAs) are a class of covalently closed, endogenous ncRNAs. Most
circRNAs are derived from exonic or intronic sequences by precursor RNA back-splicing …

Insights into the role of CircRNAs: biogenesis, characterization, functional, and clinical impact in human malignancies

S Nisar, AA Bhat, M Singh, T Karedath… - Frontiers in cell and …, 2021 - frontiersin.org
Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding
endogenous RNAs (ncRNAs) found in the eukaryotic transcriptome, originally believed to be …

riboCIRC: a comprehensive database of translatable circRNAs

H Li, M Xie, Y Wang, L Yang, Z Xie, H Wang - Genome biology, 2021 - Springer
Abstract riboCIRC is a translatome data-oriented circRNA database specifically designed for
hosting, exploring, analyzing, and visualizing translatable circRNAs from multi-species. The …

CIRCexplorer3: a CLEAR pipeline for direct comparison of circular and linear RNA expression

XK Ma, MR Wang, CX Liu, R Dong… - Genomics …, 2019 - academic.oup.com
Sequences of circular RNAs (circRNAs) produced from back-splicing of exon (s) completely
overlap with those from cognate linear RNAs transcribed from the same gene loci with the …

CircCode: a powerful tool for identifying circRNA coding ability

P Sun, G Li - Frontiers in genetics, 2019 - frontiersin.org
Circular RNAs (circRNAs), which play vital roles in many regulatory pathways, are
widespread in many species. Although many circRNAs have been discovered in plants and …

Computational approaches for circular RNA analysis

T Jakobi, C Dieterich - Wiley Interdisciplinary Reviews: RNA, 2019 - Wiley Online Library
Circular RNAs (circRNAs) are a recent addition to the expanding universe of RNA species
and originate through back‐splicing events from linear primary transcripts. CircRNAs show …

The recent advancements in circRNA research: From biogenesis to therapeutic interventions

A Malviya, R Bhuyan - Pathology-Research and Practice, 2023 - Elsevier
Circular RNAs (circRNAs) belong to the genre of long non-coding RNAs that are formed by
special back-splicing events and are currently the molecule of interest for studies globally …

Non-coding RNAs in tuberculosis epidemiology: Platforms and approaches for investigating the genome's dark matter

A Almatroudi - International Journal of Molecular Sciences, 2022 - mdpi.com
A growing amount of information about the different types, functions, and roles played by
non-coding RNAs (ncRNAs) is becoming available, as more and more research is done …