Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the
gastrointestinal tract. The majority of GISTs harbor gain of function mutations in either KIT or …

Abstract Background Soft-tissue sarcomas (STSs) are rare malignancies, accounting for
approximately 1% of adult cancer. Metastatic disease carries a poor prognosis, and various …

Anti-PD-(L) 1 therapies yield a disappointing response rate of 15% across soft-tissue
sarcomas, even if some subtypes benefit more than others. The proportions of TAMs and …

Homologous recombination and DNA repair are important for genome maintenance.
Genetic variations in essential homologous recombination genes, including BRCA1 and …

Mesenchymal gastrointestinal cancers are represented by the gastrointestinal stromal
tumors (GISTs) which occur throughout the whole gastrointestinal tract, and affect human …

Sarcomas are a rare malignancy of mesenchymal tissues, comprizing a plethora of unique
subtypes, with more than 60 types. The sheer heterogeneity of disease phenotype makes …

Dedifferentiated liposarcoma (DDL) is defined as the transition from well-differentiated
liposarcoma (WDL)/atypical lipomatous tumor (ALT) to non-lipogenic sarcoma, which arises …

Gastrointestinal stromal tumors (GISTs) are a subtype of soft tissue sarcoma (STS), and have
become a concept of oncogenic addiction and targeted therapies. The large majority of …

Liposarcomas are a common subfamily of soft tissue sarcoma with several subtypes
recognized by the World Health Organization: atypical lipomatous tumors (ALT)/well …

Simple Summary Desmoplastic small round cell tumor is a rare neoplasm with extremely
aggressive behavior. Despite the multimodal treatment for newly diagnosed patients with …