Catalyst-and Stoichiometry-Dependent Deoxygenative Reduction of Esters to Ethers or Alcohols with Borane–Ammonia

PV Ramachandran, AA Alawaed, HJ Hamann - Organic Letters, 2023 - ACS Publications
A facile and selective room temperature deoxygenation of both aromatic and aliphatic
carboxylic esters to ethers has been achieved by regulating the stoichiometry of the …

A Safer Reduction of Carboxylic Acids with Titanium Catalysis

PV Ramachandran, AA Alawaed, HJ Hamann - Organic Letters, 2022 - ACS Publications
Ammonia-borane, shown previously to react with carboxylic acids under reflux to form
primary amides, reduces acids to alcohols at room temperature in the presence of catalytic …

Ni(II)-Catalyzed Transfer Hydrogenation of Azoarenes with NH3BH3

D Gong, D Kong, Y Li, C Gao, L Zhao - Organic Letters, 2023 - ACS Publications
A nickel-catalyzed semihydrogenation of azoarenes to hydrazoarenes with NH3BH3 is
developed. The catalytic system exhibits good functional group tolerance and a high …

Balancing Lewis Acidity and Carbocation Stability for the Selective Deoxyhalogenation of Aryl Carbonyls and Carbinols

PV Ramachandran, AA Alawaed, HJ Hamann - Organic Letters, 2023 - ACS Publications
Deoxyhalogenation of aryl aldehydes, ketones, carboxylic acids, and esters has been
achieved utilizing an appropriate metal halide Lewis acid acting as a carbonyl activator and …

Dehydrocoupling of Ammonia/Amine Boranes and Related Transformations Catalysed by Group 4 Metal Complexes

M Rippke, X Tian, F Reiß, L Wu… - Chemistry–A European …, 2024 - Wiley Online Library
Ammonia boranes and amine boranes are main group analogues of alkanes, which are
characterised by their large gravimetric hydrogen content. This hydrogen can be released in …

Amidophosphine Boranes as Hydroboration Reagents for Nitriles, Alkynes, and Carboxylic Acids

R Kumar, RK Meher, J Sharma, A Sau… - Organic Letters, 2023 - ACS Publications
We report here the hydroboration of nitriles, alkynes, and carboxylic acids using
amidophosphine boranes {(BH3)(PPh2)-NC (CH3) 3},{(BH3) 2 (PPh) 2N (CH2) C6H5}, and …

TiCl 4-mediated deoxygenative reduction of aromatic ketones to alkylarenes with ammonia borane

Y Zang, Y Ma, Q Xu, G Li, N Chen, X Li… - Organic & Biomolecular …, 2024 - pubs.rsc.org
A rapid and mild protocol for the exhaustive deoxygenation of various aromatic ketones to
corresponding alkanes was described, which was mediated by TiCl4 and used ammonia …

Titanium-Mediated Reduction of Carboxamides to Amines with Borane–Ammonia

PV Ramachandran, AA Alawaed, A Singh - Molecules, 2023 - mdpi.com
In this study, the successful titanium tetrachloride-catalyzed reduction of aldehydes, ketones,
carboxylic acids, and nitriles with borane–ammonia was extended to the reduction …

TiCl4-catalyzed deoxygenative reduction of amides to amines using ammonia borane

Y Zang, Q Sui, Q Xu, M Ma, G Li, F Zhu - Tetrahedron Letters, 2023 - Elsevier
A convenient and effective TiCl 4-catalyzed procedure for the direct deoxygenative reduction
of amides to corresponding amines has been developed using safe and stable ammonia …

Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane

PV Ramachandran, AA Alawaed - Molecules, 2022 - mdpi.com
The reduction of a variety of aromatic and aliphatic nitriles, activated by a molar equivalent of
titanium tetrachloride, has been achieved at room temperature using ammonia borane as a …