Endothelial cells play critical roles in circulatory homeostasis and are also the gateway to
the major organs of the body. Dysfunction, injury, and gene expression profiles of these cells …

Liposomes are one of the most widely investigated carriers for CRISPR/Cas9 delivery. The
surface properties of liposomal carriers, including the surface charge, PEGylation, and …

Inherited kidney diseases (IKDs) are a large group of disorders affecting different nephron
segments, many of which progress towards kidney failure due to the absence of curative …

In the last years the rapid development of Nucleic Acid Based Drugs (NABDs) to be used in
gene therapy has had a great impact in the medical field, holding enormous promise …

The receptor for advanced glycation end products (RAGE) plays a central role in the chronic
inflammatory process associated with atherosclerosis development. We aimed to develop …

Glioblastoma is the most common and aggressive brain tumor. Current treatments do not
allow to cure the patients. This is partly due to the blood–brain barrier (BBB), which limits the …

Atherosclerosis, a chronic disease associated with metabolism, poses a significant risk to
human well‐being. Currently, existing treatments for atherosclerosis lack sufficient efficiency …

This investigation aimed to use CRISPR-Cas9 gene-editing to knock down P-glycoprotein (P-
gp) expression and then establish a feasible cell line to evaluate the potential …

Defects in the genome cause genetic diseases and can be treated with gene therapy. Due to
the limitations encountered in gene delivery, lipid-based supramolecular colloidal materials …

Background and Aims Changes in single microRNA (miRNA) expression have been
associated with chemo‐resistance in biliary tract cancers (BTCs). However, a global …