The sodium and potassium gradients across the plasma membrane are used by animal cells
for numerous processes, and the range of demands requires that the responsible ion pump …

The choroid plexus (CP) forming the blood–cerebrospinal fluid (B-CSF) barrier is among the
least studied structures of the central nervous system (CNS) despite its clinical importance …

The glucose transporter GLUT1 at the blood-brain barrier (BBB) mediates glucose transport
into the brain. Alzheimer's disease is characterized by early reductions in glucose transport …

PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). We found that
reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid …

The choroid plexus epithelium is a cuboidal cell monolayer, which produces the majority of
the cerebrospinal fluid. The concerted action of a variety of integral membrane proteins …

The two major interfaces separating brain and blood have different primary roles. The
choroid plexuses secrete cerebrospinal fluid into the ventricles, accounting for most net fluid …

Blood brain barrier (BBB) breakdown is not only a consequence of but also contributes to
many neurological disorders, including stroke and Alzheimer's disease. How the basement …

The Na-K-ATPase is characterized by a complex molecular heterogeneity that results from
the expression and differential association of multiple isoforms of both its α-and β-subunits …

Blood–brain barrier (BBB) together with enzymes restricts the entry of substances for
maintaining the internal milieu of the brain. Because of the presence of multiple endogenous …

Accumulation of amyloid-β (Aβ) within extracellular spaces of the brain is a hallmark of
Alzheimer disease (AD). In sporadic, late-onset AD, there is little evidence for increased Aβ …