Long-term and sequential treatment for osteoporosis

I Foessl, HP Dimai, B Obermayer-Pietsch - Nature Reviews …, 2023 - nature.com
Osteoporosis is a skeletal disorder that causes impairment of bone structure and strength,
leading to a progressively increased risk of fragility fractures. The global prevalence of …

[HTML][HTML] Advancing targeted protein degradation for metabolic diseases therapy

QQ Zhou, HT Xiao, F Yang, YD Wang, P Li… - Pharmacological …, 2023 - Elsevier
The development and application of traditional drugs represented by small molecule
chemical drugs and biological agents, especially inhibitors, have become the mainstream …

FSH blockade improves cognition in mice with Alzheimer's disease

J Xiong, SS Kang, Z Wang, X Liu, TC Kuo, F Korkmaz… - Nature, 2022 - nature.com
Alzheimer's disease has a higher incidence in older women, with a spike in cognitive
decline that tracks with visceral adiposity, dysregulated energy homeostasis and bone loss …

Menopause and women's cardiovascular health: is it really an obvious relationship?

K Ryczkowska, W Adach, K Janikowski… - Archives of medical …, 2022 - pmc.ncbi.nlm.nih.gov
Cardiovascular diseases are common for men and women but there are differences
between the sexes in terms of clinical symptoms, pathophysiology and response to the …

Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets

Y Cheng, H Zhu, J Ren, HY Wu, JE Yu, LY Jin… - Nature …, 2023 - nature.com
Follicle-stimulating hormone (FSH) is involved in mammalian reproduction via binding to
FSH receptor (FSHR). However, several studies have found that FSH and FSHR play …

The relationship between thyroid function and metabolic syndrome and its components: a cross-sectional study in a Chinese population

J He, Y Lai, J Yang, Y Yao, Y Li, W Teng… - Frontiers in …, 2021 - frontiersin.org
Objective The present study examined the relationship between thyroid function status and
the prevalence of metabolic syndrome in a Chinese population. Methods Cross-sectional …

Rodent models of nonalcoholic fatty liver disease

F Zhong, X Zhou, J Xu, L Gao - Digestion, 2020 - karger.com
Background: Nonalcoholic fatty liver disease (NAFLD) is a continuous diseases spectrum
associated with obesity, type 2 diabetes, insulin resistance, and hyperlipidemia. Simple …

[HTML][HTML] Lactic acid bacteria-derived exopolysaccharide: Formation, immunomodulatory ability, health effects, and structure-function relationship

J Zhang, Y Xiao, H Wang, H Zhang, W Chen… - Microbiological …, 2023 - Elsevier
Exopolysaccharides (EPSs) synthesized by lactic acid bacteria (LAB) have implications for
host health and act as food ingredients. Due to the variability of LAB-EPS (lactic acid …

The hepatoprotective and hepatotoxic roles of sex and sex-related hormones

L Xu, Y Yuan, Z Che, X Tan, B Wu, C Wang… - Frontiers in …, 2022 - frontiersin.org
Most liver diseases, including acute liver injury, drug-induced liver injury, viral hepatitis,
metabolic liver diseases, and end-stage liver diseases, are strongly linked with hormonal …

FSH-blocking therapeutic for osteoporosis

S Gera, TC Kuo, AA Gumerova, F Korkmaz, D Sant… - Elife, 2022 - elifesciences.org
Pharmacological and genetic studies over the past decade have established the follicle-
stimulating hormone (FSH) as an actionable target for diseases affecting millions, namely …