A new coronavirus (CoV) caused a pandemic named COVID-19, which has become a
global health care emergency in the present time. The virus is referred to as SARS-CoV-2 …

Coronavirus protease nsp5 (M pro, 3CL pro) remains a primary target for coronavirus
therapeutics due to its indispensable and conserved role in the proteolytic processing of the …

A protein in its native, folded conformation creates a solvent-exposed (exterior) surface and
a solventexcluded (interior) surface (Figure 1). Enzyme active sites are most often found at …

Thioalkyl and thioalkylated oligo (ethylene glycol)(OEG) ligands with chain-end functionality
were used to fabricate water-soluble CdSe nanoparticle scaffolds. Surface recognition of …

Many proteins exert their biological roles as components of complexes, and the functions of
proteins are often determined by their specific interactions with other proteins. Because of …

Water-soluble gold nanoparticles bearing diverse l-amino acid terminals have been
fabricated to probe the effect of receptor surface on protein surface binding. The interaction …

This book provides basic principles of multivalent interactions found in biological systems as
well as an up-to-date and thorough coverage in design concepts, syntheses, and biological …

Crystal structures have shown that the HIV‐1 protease flaps, domains that control access to
the active site, are closed when the active site is occupied by a ligand. Although flap …

The most common strategy in the development of HIV-1 protease inhibitors has been the
design of high affinity transition state analogs that effectively compete with natural substrates …

The development of inhibitors for protein–protein interactions frequently involves the mimicry
of secondary structure motifs. While helical protein–protein interactions have been heavily …