Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

Cell cycle is regulated by a number of proteins namely cyclin-dependent kinases (CDKs)
and their associated cyclins which bind with and activate CDKs in a phase specific manner …

Cancers often evade immune surveillance by adopting peripheral tissue–tolerance
mechanisms, such as the expression of programmed cell death ligand 1 (PD-L1), the …

Deleterious sustained inflammation mediated by activated microglia is common to most of
neurologic disorders. Here, we identified sirtuin 2 (SIRT2), an abundant deacetylase in the …

Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are
traditionally activated upon association with a regulatory subunit. For most CDKs, activation …

Blocking the programmed death-ligand 1 (PD-L1) on tumor cells with monoclonal antibody
therapy has emerged as powerful weapon in cancer immunotherapy. However, only a …

Despite the development of adjuvant therapies, glioblastoma (GBM) patients remain
incurable, thus justifying the urgent need of new therapies. CDK5 plays a critical role in GBM …

Purpose: Metastatic uveal melanoma represents the most common intraocular malignancy
with very poor prognosis and no effective treatments. Oncogenic mutations in the G-protein α …

The atypical cyclin-dependent kinase 5 (CDK5) is considered as a neuron-specific kinase
that plays important roles in many cellular functions including cell motility and survival. The …

Cyclin-dependent kinase, Cdk5, is an atypical but essential member of the Cdk family of
proline-directed serine/threonine kinases with no evident role in cell cycle progression …