This work summarizes our current understanding of the elongation and termination/recycling
phases of eukaryotic protein synthesis. We focus here on recent advances in the field. In …

Translation termination in eukaryotes occurs in response to a stop codon in the ribosomal A-
site and requires two release factors (RFs), eRF1 and eRF3, which bind to the A-site as an …

In eukaryotes, accurate protein synthesis relies on a family of translational GTPases that pair
with specific decoding factors to decipher the mRNA code on ribosomes. We present …

Although well defined in bacterial systems, the molecular mechanisms underlying ribosome
recycling in eukaryotic cells have only begun to be explored. Recent studies have proposed …

No‐go decay (NGD) and non‐stop decay (NSD) are eukaryotic surveillance mechanisms
that target mRNAs on which elongation complexes (ECs) are stalled by, for example, stable …

Despite some appealing similarities of protein synthesis across all phyla of life, the final
phase of mRNA translation has yet to be captured. Here, we reveal the ancestral role and …

To conserve energy during starvation and stress, many organisms use hibernation factor
proteins to inhibit protein synthesis and protect their ribosomes from damage,. In bacteria …

Living cells require the continuous production of proteins by the ribosomes. Any problem
enforcing these protein factories to stall during mRNA translation may then have deleterious …

Following translation termination, ribosomal subunits dissociate to become available for
subsequent rounds of protein synthesis. In many translation‐inhibiting stress conditions, eg …

RNA-processing pathways are at the centre of regulation of gene expression. All RNA
transcripts undergo multiple maturation steps in addition to covalent chemical modifications …