Radiomics: the facts and the challenges of image analysis
S Rizzo, F Botta, S Raimondi, D Origgi… - European radiology …, 2018 - Springer
Radiomics is an emerging translational field of research aiming to extract mineable high-
dimensional data from clinical images. The radiomic process can be divided into distinct …
dimensional data from clinical images. The radiomic process can be divided into distinct …
Radiomics: the process and the challenges
“Radiomics” refers to the extraction and analysis of large amounts of advanced quantitative
imaging features with high throughput from medical images obtained with computed …
imaging features with high throughput from medical images obtained with computed …
Whole slide images based cancer survival prediction using attention guided deep multiple instance learning networks
Traditional image-based survival prediction models rely on discriminative patch labeling
which make those methods not scalable to extend to large datasets. Recent studies have …
which make those methods not scalable to extend to large datasets. Recent studies have …
Phenotype molding of stromal cells in the lung tumor microenvironment
Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of
stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human …
stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human …
Cooperation between constitutive and inducible chemokines enables T cell engraftment and immune attack in solid tumors
We investigated the role of chemokines in regulating T cell accumulation in solid tumors.
CCL5 and CXCL9 overexpression was associated with CD8+ T cell infiltration in solid …
CCL5 and CXCL9 overexpression was associated with CD8+ T cell infiltration in solid …
CellCharter reveals spatial cell niches associated with tissue remodeling and cell plasticity
M Varrone, D Tavernari, A Santamaria-Martínez… - Nature Genetics, 2024 - nature.com
Tissues are organized in cellular niches, the composition and interactions of which can be
investigated using spatial omics technologies. However, systematic analyses of tissue …
investigated using spatial omics technologies. However, systematic analyses of tissue …
NRF2 regulates serine biosynthesis in non–small cell lung cancer
GM DeNicola, PH Chen, E Mullarky, JA Sudderth… - Nature …, 2015 - nature.com
Tumors have high energetic and anabolic needs for rapid cell growth and proliferation, and
the serine biosynthetic pathway was recently identified as an important source of metabolic …
the serine biosynthetic pathway was recently identified as an important source of metabolic …
Inferring tumour purity and stromal and immune cell admixture from expression data
K Yoshihara, M Shahmoradgoli, E Martínez… - Nature …, 2013 - nature.com
Infiltrating stromal and immune cells form the major fraction of normal cells in tumour tissue
and not only perturb the tumour signal in molecular studies but also have an important role …
and not only perturb the tumour signal in molecular studies but also have an important role …
Development and validation of an individualized immune prognostic signature in early-stage nonsquamous non–small cell lung cancer
Importance The prevalence of early-stage non–small cell lung cancer (NSCLC) is expected
to increase with recent implementation of annual screening programs. Reliable prognostic …
to increase with recent implementation of annual screening programs. Reliable prognostic …
Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer
B Győrffy, P Surowiak, J Budczies, A Lánczky - PloS one, 2013 - journals.plos.org
In the last decade, optimized treatment for non-small cell lung cancer had lead to improved
prognosis, but the overall survival is still very short. To further understand the molecular …
prognosis, but the overall survival is still very short. To further understand the molecular …