[HTML][HTML] Staphylococcus aureus Toxins: An Update on Their Pathogenic Properties and Potential Treatments

N Ahmad-Mansour, P Loubet, C Pouget… - Toxins, 2021 - mdpi.com
Staphylococcus aureus is a clinically important pathogen that causes a wide range of
human infections, from minor skin infections to severe tissue infection and sepsis. S. aureus …

Ethnobotany and the role of plant natural products in antibiotic drug discovery

G Porras, F Chassagne, JT Lyles, L Marquez… - Chemical …, 2020 - ACS Publications
The crisis of antibiotic resistance necessitates creative and innovative approaches, from
chemical identification and analysis to the assessment of bioactivity. Plant natural products …

[HTML][HTML] A systematic review of plants with antibacterial activities: A taxonomic and phylogenetic perspective

F Chassagne, T Samarakoon, G Porras… - Frontiers in …, 2021 - frontiersin.org
Background: Antimicrobial resistance represents a serious threat to human health across the
globe. The cost of bringing a new antibiotic from discovery to market is high and return on …

[HTML][HTML] Interference in bacterial quorum sensing: a biopharmaceutical perspective

B Rémy, S Mion, L Plener, M Elias… - Frontiers in …, 2018 - frontiersin.org
Numerous bacteria utilize molecular communication systems referred to as quorum sensing
(QS) to synchronize the expression of certain genes regulating, among other aspects, the …

Opportunities for natural products in 21 st century antibiotic discovery

GD Wright - Natural product reports, 2017 - pubs.rsc.org
Natural products and their derivatives are mainstays of our antibiotic drugs, but they are
increasingly in peril. The combination of widespread multidrug resistance in once …

Commensal staphylococci influence Staphylococcus aureus skin colonization and disease

CP Parlet, MM Brown, AR Horswill - Trends in microbiology, 2019 - cell.com
Commensal organisms that constitute the skin microbiota play a pivotal role in the
orchestration of cutaneous homeostasis and immune competence. This balance can be …

Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis

MR Williams, SK Costa, LS Zaramela, S Khalil… - Science translational …, 2019 - science.org
Colonization of the skin by Staphylococcus aureus is associated with exacerbation of atopic
dermatitis (AD), but any direct mechanism through which dysbiosis of the skin microbiome …

[HTML][HTML] Coagulase-negative staphylococcal strain prevents Staphylococcus aureus colonization and skin infection by blocking quorum sensing

AE Paharik, CP Parlet, N Chung, DA Todd… - Cell host & …, 2017 - cell.com
Coagulase-negative staphylococci (CoNS) and Staphylococcus aureus are part of the
natural flora of humans and other mammals. We found that spent media from the CoNS …

Natural Products That Target Virulence Factors in Antibiotic-Resistant Staphylococcus aureus

SC Wu, F Liu, K Zhu, JZ Shen - Journal of agricultural and food …, 2019 - ACS Publications
The increase in the incidence of antibiotic-resistant Staphylococcus aureus (S. aureus)
associated infections necessitates the urgent development of novel therapeutic strategies …

[HTML][HTML] Targeting ESKAPE pathogens with anti-infective medicinal plants from the Greater Mpigi region in Uganda

F Schultz, G Anywar, H Tang, F Chassagne, JT Lyles… - Scientific Reports, 2020 - nature.com
Antibiotic resistance poses one of the greatest threats to global health today; conventional
drug therapies are becoming increasingly inefficacious and limited. We identified 16 …