Organs-on-chips are microengineered microfluidic living cell culture devices with
continuously perfused chambers penetrating to cells. By mimicking the biological features of …

Biomaterials are extensively used to mimic cell–matrix interactions, which are essential for
cell growth, function, and differentiation. This is particularly relevant when developing in vitro …

Background The generation of liver organoids recapitulating parenchymal and non-
parenchymal cell interplay is essential for the precise in vitro modeling of liver diseases …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a worldwide health
epidemic with a global occurrence of approximately 30%. The pathogenesis of MASLD is a …

Human organoids-on-chips (OrgOCs) are the synergism of human organoids (HOs)
technology and microfluidic organs-on-chips (OOCs). OOCs can mimic extrinsic …

Primary liver cancers (PLC), including hepatocellular carcinoma (HCC) and
cholangiocarcinoma (CCA), are among the leading causes of cancer-related mortality …

As the largest internal organ, the liver is the key hub for many physiological processes.
Previous research on the liver has been mainly conducted on animal models and cell lines …

The evaluation of exposure to multiple contaminants in a mixture presents a number of
challenges. For example, the characterization of chemical metabolism in a mixture setting …

The present study aimed to develop viable liver organoids using decellularized native liver
scaffolds and evaluate the efficacy of human liver organoid transplantation in a rabbit model …

Liver bioengineering stands as a prominent alternative to conventional hepatic
transplantation. Through liver decellularization and/or bioprinting, researchers can generate …