Despite their known importance in clinical medicine, differences based on sex and gender
are among the least studied factors affecting cancer susceptibility, progression, survival, and …

Ageing is the single greatest cause of disease and death worldwide, and understanding the
associated processes could vastly improve quality of life. Although major categories of …

Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships …

Sex differences manifest in many diseases and may drive sex-specific therapeutic
responses. To understand the molecular basis of sex differences, we evaluated sex-biased …

Single-cell transcriptomics is a versatile tool for exploring heterogeneous cell populations,
but as with all genomics experiments, batch effects can hamper data integration and …

Although all human tissues carry out common processes, tissues are distinguished by gene
expression patterns, implying that distinct regulatory programs control tissue specificity. In …

Rare genetic diseases are typically caused by a single gene defect. Despite this clear
causal relationship between genotype and phenotype, identifying the pathobiological …

Praise for the third edition of Bioinformatics" This book is a gem to read and use in practice."—
Briefings in Bioinformatics" This volume has a distinctive, special value as it offers an …

Cardiovascular disease (CVD) is the leading cause of mortality and loss of disability
adjusted life years (DALYs) globally. CVDs like Heart Failure (HF) and Atrial Fibrillation (AF) …

Pigs are a valuable human biomedical model and an important protein source supporting
global food security. The transcriptomes of peripheral blood immune cells in pigs were …