Genome-wide sex and gender differences in cancer
CM Lopes-Ramos, J Quackenbush… - Frontiers in oncology, 2020 - frontiersin.org
Despite their known importance in clinical medicine, differences based on sex and gender
are among the least studied factors affecting cancer susceptibility, progression, survival, and …
are among the least studied factors affecting cancer susceptibility, progression, survival, and …
Ageing hallmarks exhibit organ-specific temporal signatures
Ageing is the single greatest cause of disease and death worldwide, and understanding the
associated processes could vastly improve quality of life. Although major categories of …
associated processes could vastly improve quality of life. Although major categories of …
A reference map of the human binary protein interactome
Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships …
understanding of the interactome networks that mediate genotype–phenotype relationships …
[HTML][HTML] Sex differences in gene expression and regulatory networks across 29 human tissues
Sex differences manifest in many diseases and may drive sex-specific therapeutic
responses. To understand the molecular basis of sex differences, we evaluated sex-biased …
responses. To understand the molecular basis of sex differences, we evaluated sex-biased …
A test metric for assessing single-cell RNA-seq batch correction
Single-cell transcriptomics is a versatile tool for exploring heterogeneous cell populations,
but as with all genomics experiments, batch effects can hamper data integration and …
but as with all genomics experiments, batch effects can hamper data integration and …
Understanding tissue-specific gene regulation
Although all human tissues carry out common processes, tissues are distinguished by gene
expression patterns, implying that distinct regulatory programs control tissue specificity. In …
expression patterns, implying that distinct regulatory programs control tissue specificity. In …
Network analysis reveals rare disease signatures across multiple levels of biological organization
Rare genetic diseases are typically caused by a single gene defect. Despite this clear
causal relationship between genotype and phenotype, identifying the pathobiological …
causal relationship between genotype and phenotype, identifying the pathobiological …
[图书][B] Bioinformatics
AD Baxevanis, GD Bader, DS Wishart - 2020 - books.google.com
Praise for the third edition of Bioinformatics" This book is a gem to read and use in practice."—
Briefings in Bioinformatics" This volume has a distinctive, special value as it offers an …
Briefings in Bioinformatics" This volume has a distinctive, special value as it offers an …
[HTML][HTML] Investigating genes associated with heart failure, atrial fibrillation, and other cardiovascular diseases, and predicting disease using machine learning …
Cardiovascular disease (CVD) is the leading cause of mortality and loss of disability
adjusted life years (DALYs) globally. CVDs like Heart Failure (HF) and Atrial Fibrillation (AF) …
adjusted life years (DALYs) globally. CVDs like Heart Failure (HF) and Atrial Fibrillation (AF) …
Reference transcriptomes of porcine peripheral immune cells created through bulk and single-cell RNA sequencing
Pigs are a valuable human biomedical model and an important protein source supporting
global food security. The transcriptomes of peripheral blood immune cells in pigs were …
global food security. The transcriptomes of peripheral blood immune cells in pigs were …