Developing biomedical engineering technologies for reproductive medicine

Y Zhu, B Kong, R Liu, Y Zhao - Smart Medicine, 2022 - Wiley Online Library
Infertility is a rising global health issue with a far‐reaching impact on the socioeconomic
livelihoods. As there are highly complex causes of male and female infertility, it is highly …

Epigenetics of male infertility: the role of DNA methylation

JC Rotondo, C Lanzillotti, C Mazziotta… - Frontiers in Cell and …, 2021 - frontiersin.org
In recent years, a number of studies focused on the role of epigenetics, including DNA
methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the …

Oxidative stress mediated by the TLR4/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice

H Wu, T Xu, T Chen, J Liu, S Xu - Science of the Total Environment, 2022 - Elsevier
Microplastics (MPs), as a new environmental pollutant, have received widespread attention
worldwide. Uterine fibrosis is one of the main factors of female reproductive disorders …

The effect of underweight on female and male reproduction

C Boutari, PD Pappas, G Mintziori, MP Nigdelis… - Metabolism, 2020 - Elsevier
Chronic energy deficiency can impair the hypothalamic-pituitary-gonadal (HPG) axis and
lead to hypothalamic anovulation in underweight women. This review presents the …

Molecular signaling regulating endometrium–blastocyst crosstalk

M Massimiani, V Lacconi, F La Civita, C Ticconi… - International journal of …, 2019 - mdpi.com
Implantation of the embryo into the uterine endometrium is one of the most finely-regulated
processes that leads to the establishment of a successful pregnancy. A plethora of factors …

Female infertility and herbal medicine: An overview of the new findings

M Akbaribazm, N Goodarzi… - Food science & …, 2021 - Wiley Online Library
Infertility is defined as the failure to achieve a successful pregnancy after 12 months' sexual
activity that affects 15%–17% of couples in the world and about 50% of them are related to …

A tissue-engineered uterus supports live births in rabbits

RS Magalhaes, JK Williams, KW Yoo, JJ Yoo… - Nature …, 2020 - nature.com
Bioengineered uterine tissue could provide a treatment option for women with uterine factor
infertility. In large animal models, reconstruction of the uterus has been demonstrated only …

Human papillomavirus infection and fertility alteration: a systematic review

T Souho, M Benlemlih, B Bennani - PloS one, 2015 - journals.plos.org
Background HPV is the most prevalent sexually transmitted infection and its effect in cancer
induction is well documented. HPV infections are mostly asymptomatic, but it is unclear …

Expectant, medical, and surgical management of ovarian endometriomas

L Muzii, G Galati, G Mattei, A Chinè, G Perniola… - Journal of Clinical …, 2023 - mdpi.com
Management options for ovarian endometriomas include expectant management, medical
treatment, surgical treatment, in vitro fertilization (IVF), or a combination of the above. The …

Epigenetic factors in eutopic endometrium in women with endometriosis and infertility

M Adamczyk, E Wender-Ozegowska… - International Journal of …, 2022 - mdpi.com
Eutopic endometrium in patients with endometriosis is characterized by aberrant expression
of essential genes during the implantation window. It predisposes to disturbance of …