Ovarian aging in women correlates with the progressive loss of both the number and quality
of oocytes. When these processes occur early or are accelerated, their clinical correlates are …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …

Mitochondrial DNA content varies considerably in oocytes, even when collected from the
same patient. In the present study, real-time quantitative polymerase chain reaction analysis …

As women delay childbearing because of demographic and socioeconomic trends,
reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent …

Mitochondria play a vital role in the metabolism of energy-containing compounds in the
oocyte cytoplasm to provide adenosine trisphosphate for fertilization and preimplantation …

OBJECTIVE: To determine the content of mitochondrial DNA (mtDNA) in oocytes from a
range of patients with fertilization success and failure. DESIGN: Analysis of mtDNA content …

The oocyte requires a vast supply of energy after fertilization to support critical events such
as spindle formation, chromatid separation, and cell division. Until blastocyst implantation …

The role of metabolism in ovarian aging is poorly described, despite the fact that ovaries fail
earlier than most other organs. Growing interest in ovarian function is being driven by recent …

В монографии изложены современные представления об этиологии и патогенезе
хромосомных болезней. Рассмотрены основные стадии гаметогенеза и эмбриогенеза …