Based on recent findings indicating that metabolism might be governed by a limit on the rate
at which cells can dissipate Gibbs energy, in this Perspective, we propose a new …

Nearly three-fourths of all eukaryotic DNA is occupied by nucleosomes, protein–DNA
complexes comprising octameric histone core proteins and∼ 150 base pairs of DNA. In …

The most common gene regulation mechanism is when a transcription factor (TF) protein
binds to a regulatory sequence to increase or decrease RNA transcription. However, TFs …

In a process known as facilitated diffusion, DNA-binding proteins find their target sites by
combining three-dimensional diffusion and one-dimensional scanning of the DNA …

Cells regulate fates and complex body plans using spatiotemporal signaling cascades that
alter gene expression. Short DNA sequences, known as enhancers (50–1500 base pairs) …

Many fundamental biophysical processes involving gene regulation and gene editing rely, at
the molecular level, on an intricate methodology of searching and locating the precise target …

Multi-exponential waiting-time distribution and randomness parameter greater than unity
ascribe dynamic disorder in single-enzyme catalysis corroborated to the interplay of …

Cells regulate fates and complex body plans using spatiotemporal signaling cascades that
alter gene expression. Enhancers, short DNA sequences (50-150 base pairs), help …

The binding of proteins to their respective specific sites on the DNA through facilitated
diffusion serves as the initial step of various important biological processes. While this …

Quorum sensing (QS) is a bacterial communication process in which cells detect the local
environment and collectively activate gene expression. The transcriptional activator (LuxR) …