Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by a reciprocal
translocation [t (9; 22)(q34; q11. 2)] that leads to the fusion of ABL1 gene sequences (9q34) …

The truncated chromosome 22 that results from the reciprocal translocation t (9; 22)(q34;
q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid …

Chronic myeloid leukaemia (CML) is a myeloproliferative disorder arising in the
haemopoietic stem cell (HSC) compartment. This disease is characterised by a reciprocal t …

The BCR-ABL1 oncoprotein transforms pluripotent HSCs and initiates chronic myeloid
leukemia (CML). Patients with early phase (also known as chronic phase [CP]) disease …

Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that
evolve through a multi-step process. CML is also one of the best examples of a disease that …

We showed that Eμ-MiR-155 transgenic mice develop acute lymphoblastic leukemia/high-
grade lymphoma. Most of these leukemias start at approximately 9 months irrespective of the …

Chronic myeloid leukemia (CML) is characterized by the presence of the BCR-ABL1 fusion
gene, which encodes a constitutive active tyrosine kinase considered to be the pathogenic …

Rationale: In the bone marrow microenvironment (BMME), mesenchymal stem/stromal cells
(MSCs) control the self-renewal of both healthy and cancerous hematopoietic …

Monocyte/macrophages play an important role in orchestrating the immune response. The
present review refers to C/EBPβ, which is a key transcription factor regulating monocytic …

Acute myeloid leukemia (AML) is one of the malignant hematological cancers with high
mortality. Finding a more effective and readily available treatment is of the utmost …