[HTML][HTML] Dendritic cell subsets in cancer immunity and tumor antigen sensing
Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …
[HTML][HTML] Detection of viral infections by innate immunity
Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral
innate immune system as they detect conserved viral pathogen-associated molecular …
innate immune system as they detect conserved viral pathogen-associated molecular …
AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence
Inflammasomes are important sentinels of innate immune defence, sensing pathogens and
inducing cell death in infected cells. There are several inflammasome sensors that each …
inducing cell death in infected cells. There are several inflammasome sensors that each …
Context-dependent functions of pattern recognition receptors in cancer
SM Man, BJ Jenkins - Nature Reviews Cancer, 2022 - nature.com
The immune system plays a critical role in shaping all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …
initiation stage through to metastatic disease and resistance to therapy. Our understanding …
[HTML][HTML] Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment
P Zhu, ZR Ke, JX Chen, SJ Li, TL Ma… - Frontiers in …, 2023 - frontiersin.org
PANoptosis, a new research hotspot at the moment, is a cell death pattern in which
pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence …
pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence …
[HTML][HTML] Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
LQ Wang, T Liu, S Yang, L Sun, ZY Zhao, LY Li… - Nature …, 2021 - nature.com
Perfluoroalkyl substances (PFAS) are widely used in various manufacturing processes.
Accumulation of these chemicals has adverse effects on human health, including …
Accumulation of these chemicals has adverse effects on human health, including …
AIM2 in health and disease: Inflammasome and beyond
P Kumari, AJ Russo, S Shivcharan… - Immunological …, 2020 - Wiley Online Library
Nucleic acid sensing is a critical mechanism by which the immune system monitors for
pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial …
pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial …
NLRP3 inflammasome as a key driver of vascular disease
M Takahashi - Cardiovascular research, 2022 - academic.oup.com
Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3
(NLRP3) is an intracellular innate immune receptor that recognizes a diverse range of …
(NLRP3) is an intracellular innate immune receptor that recognizes a diverse range of …
Innate immune inflammatory cell death: PANoptosis and PANoptosomes in host defense and disease
W Chen, JM Gullett, RE Tweedell… - European Journal of …, 2023 - Wiley Online Library
Regulated cell death (RCD) triggered by innate immune activation is an important strategy
for host survival during pathogen invasion and perturbations of cellular homeostasis. There …
for host survival during pathogen invasion and perturbations of cellular homeostasis. There …
Neutrophil extracellular traps augmented alveolar macrophage pyroptosis via AIM2 inflammasome activation in LPS-induced ALI/ARDS
H Li, Y Li, C Song, Y Hu, M Dai, B Liu… - Journal of Inflammation …, 2021 - Taylor & Francis
Background Uncontrollable inflammation is a critical feature of gram-negative bacterial
pneumonia-induced acute respiratory distress syndrome (ARDS). Both neutrophils and …
pneumonia-induced acute respiratory distress syndrome (ARDS). Both neutrophils and …